Research Keyword: immune response modulation

The P-type calcium pump Spf1 regulates immune response by maintenance of the endoplasmic reticulum-plasma membrane contacts during Candida albicans systemic infection

A fungal pump protein called Spf1 helps Candida albicans secrete toxins that damage the immune system during infection. When researchers deleted the SPF1 gene, the fungus could not effectively release these toxins, triggering a much weaker immune response and allowing infected mice to survive better. This discovery suggests that controlling this calcium pump could be a new strategy for treating serious fungal infections.

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Dectin-1 and dectin-2 drive protection against Sporothrix brasiliensis in experimental sporotrichosis

Scientists studied how the body’s immune system defends against Sporothrix brasiliensis, a dangerous fungus spreading through Latin America. They found that two immune receptors called dectin-1 and dectin-2 are crucial for fighting this infection by activating killer T cells and controlling regulatory T cells. Surprisingly, a cytokine called IL-17, commonly associated with fungal defense, actually helps maintain tissue integrity rather than directly killing the fungus.

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