immune evasion – Page 2

Protein kinase A signaling regulates immune evasion by shaving and concealing fungal β-1,3-glucan

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Candida albicans is a fungus that causes infections in humans. The fungus has developed a clever way to hide from our immune system by covering up a molecule on its surface called β-1,3-glucan that normally triggers immune responses. This study shows that the fungus masks this molecule through a combination of growing and dividing to create new surfaces, and then using enzymes to trim away exposed molecules. The research reveals that a specific cell signaling pathway controlled by lactate (a chemical found in our bodies) activates this masking behavior, helping the fungus evade immune recognition.

Pathogenic characterization of Phialophora submersa, a new black yeast isolated from freshwater sediments in Spain

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Scientists discovered a new black yeast fungus called Phialophora submersa in Spanish river sediments and tested whether it could infect humans. Using laboratory macrophage (immune cell) models, they found that this environmental fungus exhibits pathogenic potential similar to known disease-causing Phialophora species, though at intermediate levels. The fungus showed resistance to some antifungal drugs and displayed strain-dependent ability to survive various stress conditions. This research suggests that environmental fungal species may pose unexpected health risks despite not being able to grow at normal human body temperature.

Cgm1 is a β-galactoside α-(1 → 4)-mannosyltransferase involved in the biosynthesis of capsular glucuronoxylomannogalactan in Cryptococcus neoformans

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Researchers identified a new fungal enzyme called Cgm1 that helps the fungus Cryptococcus neoformans build its protective capsule, which allows it to evade the immune system. When this enzyme is disabled, the fungus becomes weak at body temperature and triggers a stronger immune response in infected mice. Since humans and plants don’t have this enzyme, it could be a promising target for developing new antifungal medications.

Research Keyword: immune evasion

Protein kinase A signaling regulates immune evasion by shaving and concealing fungal β-1,3-glucan

Pathogenic characterization of Phialophora submersa, a new black yeast isolated from freshwater sediments in Spain

Cgm1 is a β-galactoside α-(1 → 4)-mannosyltransferase involved in the biosynthesis of capsular glucuronoxylomannogalactan in Cryptococcus neoformans