Research Keyword: IL-8

Structural Elucidation of Heteropolysaccharides from the Peach-Shaped Dictyophora indusiata and Its Anti-Inflammatory Activity

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Researchers extracted polysaccharides from peach-shaped bamboo fungus (Dictyophora indusiata) and discovered they contain beneficial beta-glucans. When tested on human immune cells triggered to become inflamed, these polysaccharides reduced inflammatory markers and messenger proteins. The compounds were found to be chemically stable under various conditions, suggesting potential use as a natural anti-inflammatory supplement or food ingredient.

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The Effect of Combined Treatment of Psilocybin and Eugenol on Lipopolysaccharide-Induced Brain Inflammation in Mice

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This study tested whether psilocybin (an active compound from magic mushrooms) combined with eugenol (a natural compound from cloves) could reduce brain inflammation in mice. Researchers gave mice a substance that triggers inflammation in the brain and then treated them with these compounds before or after the inflammation started. The combination treatment, especially at a 1:50 ratio of psilocybin to eugenol, significantly reduced multiple inflammatory markers in the brain, suggesting this combination could potentially be helpful for treating brain inflammation-related conditions.

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Flammulina velutipes polysaccharides exhibit potent antioxidant and anti-pyroptotic properties in diabetes-associated periodontitis: A preliminary in vitro study

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Researchers studied a compound from the Flammulina velutipes mushroom (enoki mushroom) to see if it could help protect gum tissue in people with both diabetes and gum disease. Using human gum cell samples exposed to disease-simulating conditions, they found that the mushroom polysaccharides reduced cell damage, decreased inflammation, and prevented a harmful type of cell death called pyroptosis. The results suggest this mushroom compound could potentially be used as a supplementary treatment for people with diabetes-related gum disease.

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A 3D Fusarium keratitis model reveals isolate-specific adhesion and invasion properties in the Fusarium solani species complex

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Researchers studied three species of Fusarium fungus that cause serious eye infections. They found that one species (F. keratoplasticum) is much more dangerous than the others, invading deeper into the eye and causing more damage. Using a new 3D model that mimics the structure of the human cornea, they discovered that Fusarium fungi penetrate much deeper than other fungal pathogens, which helps explain why eye infections from these fungi are so difficult to treat and why patients often lose their vision.

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