Evaluation of the combined efficacy of inhibitors of heat shock protein 90 and calcineurin with commonly used antifungals against Aspergillus, Rhizopus, and Fusarium isolates
mycolabadmin
Scientists tested combinations of common antifungal medications with special inhibitor drugs that target fungal stress-response systems. When combined, these drugs worked better together against dangerous mold infections like Aspergillus and Rhizopus, especially those that are resistant to standard treatments. The combinations rarely caused harmful interactions and often enhanced the antifungal effects, suggesting this approach could improve treatment of serious mold infections.