Research Keyword: hospital-acquired infections

Influenza-related invasive pulmonary aspergillosis in an infectious disease ward at a pulmonary referral center in Iran

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This study examined patients hospitalized with influenza who developed a serious fungal infection caused by Aspergillus fungus. Among 109 influenza patients, about 9% developed this fungal complication which significantly increased their risk of death and required longer hospital stays. Patients with existing lung diseases were at higher risk, and those with the fungal infection also had more bacterial superinfections. The findings highlight the importance of recognizing and treating this serious fungal complication in hospitalized influenza patients.

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Prevalence and antifungal susceptibility profiles of Candida isolates among patients with candiduria: a multiplex PCR assay

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Researchers studied fungal infections in urine samples from hospitalized patients and found that while the common yeast Candida albicans was most prevalent, other Candida species were increasingly resistant to antifungal medications. Using advanced genetic testing methods, they identified seven different Candida species and tested their resistance to three common antifungal drugs. The findings highlight the growing problem of drug-resistant fungal infections and the need for better diagnostic tools to identify which species is causing infection so appropriate treatment can be selected.

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Healthcare-associated fungal infections and emerging pathogens during the COVID-19 pandemic

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During the COVID-19 pandemic, fungal infections became a major health concern, especially in hospitalized patients. Treatments for COVID-19, such as steroids and immunosuppressive drugs, weakened patients’ immune systems, making them vulnerable to serious fungal infections like those caused by Candida auris. Current antifungal medications have significant side effects and many fungi are developing resistance, so scientists are urgently seeking safer and more effective antifungal treatments.

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Genotypic and Phenotypic Investigation of Clinical Aspergillus isolates from Iran Indicates Nosocomial Transmission Events of Aspergillus flavus

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Researchers studied fungal infections caused by Aspergillus species in Iranian hospitals from 2020 to 2023. They found that Aspergillus flavus was the most common cause of infection and discovered evidence of several hospital-related outbreaks through genetic analysis. All isolates tested were susceptible to current antifungal medications, but the discovery of hospital transmission suggests the need for better infection control measures like improved air filtration in hospitals.

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Prevalence of fungi and their antifungal and disinfectant resistance in hospital environments: insights into combating nosocomial mycoses

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This study examined how fungal infections spread in hospital settings by testing air and surfaces in Iranian hospital intensive care units. Researchers found that dangerous fungi like Aspergillus and Rhizopus were commonly present, especially in air ducts, and many of these fungi could resist common antifungal medications and disinfectants. The findings suggest that hospital environments serve as sources of infection for vulnerable patients and that better cleaning and air filtration systems are needed to protect hospitalized patients.

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Investigating the Increasing Azole Resistance in Candida Infections Among Critically Ill Patients: Experience From a Tertiary-Level Setup in North India

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This study tracked the increase in drug-resistant yeast infections in hospitalized patients in India from 2023 to 2025. The researchers found that common antifungal medications like fluconazole are becoming less effective, with resistance rates nearly doubling over the study period. The good news is that newer antifungal drugs called echinocandins remained highly effective. The findings highlight the need for better infection control measures and more careful use of antifungal medications.

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Changing Climate, Changing Candida: Environmental and Social Pressures on Invasive Candidiasis and Antifungal Resistance in Latin America

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Invasive fungal infections caused by Candida species are becoming increasingly common and dangerous in Latin American hospitals, with newer strains showing resistance to multiple antifungal drugs. Rising temperatures from climate change and widespread use of fungicides in agriculture appear to be selecting for these resistant fungi. Most hospitals in the region lack advanced diagnostic tools to quickly identify which fungal strain is causing infection, leading to delayed and sometimes inappropriate treatment. Implementing better diagnostic access, stricter antifungal use policies, and coordinated surveillance programs across the region could help control this growing public health problem.

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