hospital-acquired infection

Development of reverse transcription loop-mediated isothermal amplification-based assay for rapid and specific detection of human fungal pathogen, Candida auris

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Researchers developed a new rapid test called RT-LAMP to detect Candida auris, a dangerous multidrug-resistant fungus that causes hospital infections. The test works by changing color from pink to yellow when the fungus is present, making it easy to read without special equipment. It is more sensitive and specific than current methods, can be done quickly at a single temperature, and costs much less than existing tests, making it ideal for hospitals and clinics with limited resources.

Prevalence and antifungal susceptibility profiles of Candida isolates among patients with candiduria: a multiplex PCR assay

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Researchers studied urinary tract infections caused by yeast (Candida species) in hospitalized patients. Using advanced molecular testing, they found that while the common yeast Candida albicans was most prevalent, other yeast species were increasingly showing resistance to antifungal medications, particularly to fluconazole. The study highlights the importance of identifying which specific yeast species is causing an infection to choose the most effective treatment.

Detection of Multiple Nosocomial Trichosporon asahii Transmission Events via Microsatellite Typing Assay, South America

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Researchers developed a new genetic fingerprinting test to track and identify outbreaks of a dangerous fungal infection called Trichosporon asahii in hospitals across South America. The test uses microsatellite markers to create a detailed genetic profile of different fungal isolates, making it much better at detecting when infections spread from patient to patient compared to older methods. This discovery revealed multiple hidden disease clusters in hospitals, including one that occurred over 13 years, highlighting the importance of this new surveillance tool for hospital infection control.

Epidemiology of Candidemia, Candiduria and Emerging Candidozyma (Candida) auris Across Gulf Cooperative Council Countries and Yemen in the Arabian Peninsula

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This comprehensive review examines fungal bloodstream and urinary tract infections caused by Candida species across Middle Eastern countries. The study shows that while Candida albicans remains common, dangerous antibiotic-resistant strains like Candidozyma auris are increasingly appearing in hospitals. The research highlights that better diagnostic tools and infection prevention practices are urgently needed in the region to protect patients and reduce deaths from these serious infections.

Prevalence and antifungal susceptibility profiles of Candida isolates among patients with candiduria: a multiplex PCR assay

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Researchers studied yeast infections in urine from hospitalized patients using advanced molecular testing. They found that while Candida albicans was most common, other yeast species were becoming more resistant to antifungal medications. The study used a 21-tube PCR test to identify different yeast species and tested which medications worked best against them. Results showed that newer yeast species were much more likely to resist commonly used antifungal drugs like fluconazole.

Invasive Candidiasis in Contexts of Armed Conflict, High Violence, and Forced Displacement in Latin America and the Caribbean (2005–2025)

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Invasive candidiasis, a serious fungal blood infection caused by Candida species, is a major health crisis in Latin America and the Caribbean with death rates reaching 60% in vulnerable populations. The disease is worsening in areas affected by armed conflict, violence, and displacement where poor living conditions, overcrowding, malnutrition, and lack of healthcare create ideal conditions for the infection to develop and spread. Antifungal drugs are often unavailable or too expensive, and drug-resistant strains of Candida are becoming increasingly common, making treatment extremely challenging in these regions.

Gastrointestinal and Intra-Abdominal Mucormycosis in Non-Haematological Patients—A Comprehensive Review

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This review examines a serious but rare fungal infection called mucormycosis that affects the stomach and intestines. The infection most commonly occurs in patients with diabetes, those who have received organ transplants, or those in intensive care units. Diagnosis can be difficult because symptoms are non-specific, but prompt treatment with antifungal medications and surgery when possible significantly improves survival rates. Early recognition and rapid diagnosis are critical for patients to have the best outcomes.

Nosocomial Diarrhea Distribution by Cryptosporidium in Isfahan

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Researchers tested 217 patients who developed diarrhea in a hospital in Isfahan, Iran to see if a parasite called Cryptosporidium was responsible. Using advanced DNA testing, they found the parasite in only 2 out of 217 patients (less than 1%). This suggests that while this parasite can spread in hospitals, it is not a major cause of diarrhea in this particular hospital, which likely has good hygiene practices.

Research Keyword: hospital-acquired infection