Research Keyword: HIV

Disseminated histoplasmosis with bone marrow infiltration in a newly diagnosed HIV patient

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A Colombian patient living in Spain developed a serious fungal infection (histoplasmosis) that spread throughout his body and affected his bone marrow, which was discovered during his HIV diagnosis. Doctors identified the infection by examining bone marrow cells under a microscope and confirmed it with fungal culture and genetic testing. The patient was treated with antifungal medication (liposomal amphotericin B) along with HIV medications and recovered well, highlighting the importance of bone marrow testing in severely immunocompromised HIV patients.

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Ex Vivo Host Transcriptomics During Cryptococcus neoformans, Cryptococcus gattii, and Candida albicans Infection of Peripheral Blood Mononuclear Cells From South African Volunteers

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Researchers studied how human immune cells respond to three different fungal infections that commonly affect people with weakened immune systems. By examining gene activity in blood cells exposed to these fungi, they discovered that each fungus triggers different immune responses, with Candida albicans causing a much stronger reaction than the two Cryptococcus species. Only one shared immune pathway was activated by all three fungi, suggesting each infection requires different immune mechanisms to fight off. These findings could help develop new treatments for serious fungal infections.

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