histopathology – mycolab.ai

Efficacy of Lacticaseibacillus rhamnosus probiotic strains in treating chromate induced dermatitis

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This research shows that a beneficial bacteria called Lacticaseibacillus rhamnosus can help treat skin problems caused by chromate exposure, a common hazard for construction workers and factory employees. The bacteria work by reducing toxic chromate to a less harmful form through a special protein called flavin reductase. When tested on mice with chromate-induced skin damage, the probiotic treatment significantly improved skin healing and reduced inflammation. This suggests these beneficial bacteria could offer a safe, natural treatment for occupational skin conditions caused by heavy metal exposure.

Phaeohyphomycosis caused by Rhinocladiella similis mimicking Sporotrichosis

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A 34-year-old factory worker developed multiple nodules on his hand following an injury, initially suspected to be sporotrichosis, a common fungal infection. Through laboratory testing including fungal culture and genetic sequencing, doctors identified the actual cause as a rare fungus called Rhinocladiella similis. The patient was successfully treated with antifungal medication and showed gradual improvement. This is the first case of this fungal infection reported in India.

Phytochemical Analysis and Anti-Ulcer Potential of Phenolic Compounds of Inonotus nidus-pici Pilát

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Researchers studied a wood mushroom called Inonotus nidus-pici to understand its healing potential. They found it contains beneficial compounds like quercetin and rosmarinic acid that act as antioxidants. When tested on rats with chemically-induced stomach ulcers, the mushroom extract provided protection similar to common ulcer medications, suggesting it could help prevent stomach damage from pain relievers.

Nannizziopsis arthrosporioides infection mimicking ophidiomycosis in ball pythons (Python regius)

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A wild-caught boa snake developed severe skin lesions caused by a fungus called Nannizziopsis arthrosporioides. Within a week, six ball pythons housed nearby developed similar skin infections. Using DNA testing and microscopy, researchers confirmed this was the first documented case of this fungus infecting snakes, demonstrating how quickly fungal infections can spread between animals in shared environments.

Antifungal Efficacy of Luliconazole-Loaded Nanostructured Lipid-Carrier Gel in an Animal Model of Dermatophytosis

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Researchers developed a new antifungal gel containing luliconazole loaded into tiny lipid nanoparticles to treat stubborn fungal skin infections caused by Trichophyton indotineae that resist standard terbinafine treatment. Testing in guinea pigs showed this new nanoformulation penetrated skin better and cleared infections faster (21 days) compared to regular luliconazole gel (28 days) and terbinafine-treated animals. The nanoparticle delivery system improved the drug’s ability to reach infected skin layers and showed no harmful side effects, offering promise for treating resistant fungal infections in patients.

Mediastinal cryptococcoma as part of disseminated cryptococcosis in HIV-negative pregnant woman with Myasthenia Gravis: Autopsy case report

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A 29-year-old pregnant woman with myasthenia gravis, a condition requiring long-term immune-suppressing medications, died from a widespread fungal infection caused by Cryptococcus. Despite being HIV-negative, her weakened immune system made her vulnerable to this serious infection. An autopsy revealed the infection had spread throughout her body, including her heart, brain, lungs, and kidneys. This case highlights how fungal infections like cryptococcosis can affect people without HIV when their immune systems are compromised by other conditions or medications.

The impact of osteoarticular invasion by Coccidioides Sp disseminated infection

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A 48-year-old man from Mexico developed a serious fungal infection caused by Coccidioides, which spread from his lungs to his skin, bones, and joints, causing pain and swelling. Despite having a normally functioning immune system, he developed progressive disease that was initially misdiagnosed as rheumatoid arthritis. After switching to the antifungal medication fluconazole, his condition improved dramatically, with symptoms resolving within several months of treatment.

Fatal Pneumonia Caused by Beauveria bassiana in a Kemp’s Ridley Sea Turtle (Lepidochelys kempii, Garman, 1880) on the Portuguese Coast: Case Report and Review of Beauveria spp. Infections in Reptiles

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A young Kemp’s ridley sea turtle, one of the world’s most endangered turtle species, was found off the coast of Portugal and brought to a rehabilitation center. Despite intensive care, the turtle died after 11 days due to a severe fungal lung infection caused by Beauveria bassiana, a fungus that normally infects insects. This case highlights how endangered animals in poor health are vulnerable to opportunistic infections and emphasizes the importance of including fungal disease screening in wildlife rehabilitation programs.

Detection and diagnostic process of liver abscess secondary to chemotherapy by mucor indicus in a patient with acute leukemic disease: case report

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A 60-year-old man with acute leukemia developed a serious fungal infection in his liver caused by Mucor indicus after receiving chemotherapy that weakened his immune system. Doctors identified the infection through tissue samples and genetic testing, then treated him successfully with antifungal medications amphotericin B and posaconazole. This case highlights the importance of early detection and proper diagnosis of rare fungal infections in cancer patients undergoing chemotherapy.

Simultaneous infection with Fusarium proliferatum and Prototheca wickerhamii localized at different body sites

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An 81-year-old woman taking long-term steroid medication developed two different fungal skin infections on her hands simultaneously – one on the right hand from a moldy wooden frame and one on the left hand possibly from sewage exposure. Doctors identified both fungi through microscopy and genetic testing. She was successfully treated with an antifungal medication called voriconazole for four weeks and recovered completely.

Research Keyword: histopathology