Research Keyword: histone acetylation

A Novel Erinacine S Derivative from Hericium erinaceus Overcomes Chemoresistance in Colorectal Cancer Cells by Enhancing TRAIL/TNFR1/DR5 Expression through Histone Acetylation

mycolabadmin

This study shows that erinacine S, a natural compound from Lion’s Mane mushrooms, can help overcome drug resistance in colorectal cancer cells. The compound works by activating pathways that trigger cancer cell death and by modifying how genes are expressed at the molecular level. In both laboratory experiments and animal models, erinacine S successfully stopped tumor growth and killed resistant cancer cells, suggesting it could be a promising natural treatment for patients with hard-to-treat colorectal cancer.

Read More »

A Novel Erinacine S Derivative from Hericium erinaceus Overcomes Chemoresistance in Colorectal Cancer Cells by Enhancing TRAIL/TNFR1/DR5 Expression through Histone Acetylation

mycolabadmin

Researchers found that erinacine S, a compound from Lion’s Mane mushroom, can help kill colorectal cancer cells that have become resistant to chemotherapy drugs. The compound works by activating death pathways in cancer cells and modifying how genes are expressed. In mouse studies, erinacine S significantly reduced tumor growth compared to standard chemotherapy alone. This suggests Lion’s Mane mushroom derivatives could potentially be developed as a natural treatment option for patients with drug-resistant colorectal cancer.

Read More »

Comprehensive analysis of the mechanisms conferring resistance to phenamacril in the Fusarium species

mycolabadmin

Fusarium fungi cause serious diseases in crops like wheat, rice, and vegetables worldwide, leading to significant food losses and contamination with harmful toxins. Phenamacril is a modern fungicide designed to fight these fungi by targeting a specific protein called myosin-5. However, the fungi have developed resistance to this fungicide through genetic changes and other mechanisms, making it less effective over time. Farmers need to use multiple strategies including crop rotation and resistant plant varieties rather than relying only on fungicides to successfully manage these diseases.

Read More »

Polyamine Induction of Secondary Metabolite Biosynthetic Genes in Fungi Is Mediated by Global Regulator LaeA and α-NAC Transcriptional Coactivator: Connection to Epigenetic Modification of Histones

mycolabadmin

Polyamines are natural compounds that act like chemical switches controlling how fungi produce useful medicines like antibiotics and statins. These molecules work by attaching to DNA and modifying histone proteins, which turns on or off the genes responsible for making pharmaceutical compounds. This research reveals that understanding polyamine control could help scientists increase antibiotic production and make plants more resistant to fungal diseases.

Read More »
Scroll to Top