Hirshfeld surface analysis

Identification of two novel thiazolidin-2-imines as tyrosinase inhibitors: synthesis, crystal structure, molecular docking and DFT studies

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Scientists created two new chemical compounds that are much better at slowing down the enzyme tyrosinase, which is responsible for skin darkening and browning of foods. These compounds were tested both in the lab and using computer models, and they worked about 14 times better than kojic acid, a commonly used anti-darkening ingredient. The research suggests these new compounds could be useful in cosmetics, food preservation, and treating skin conditions like unwanted pigmentation.

Acetophenone-Based 3,4-Dihydropyrimidine-2(1H)-Thione as Potential Inhibitor of Tyrosinase and Ribonucleotide Reductase: Facile Synthesis, Crystal Structure, In-Vitro and In-Silico Investigations

mycolabadmin

Scientists created a new chemical compound that shows promise in fighting skin cancer, particularly melanoma. The compound is seven times more effective at blocking tyrosinase, an enzyme involved in skin pigmentation and cancer growth, compared to existing drugs. Computer simulations and laboratory tests confirmed that this compound can also interfere with DNA replication processes that cancer cells depend on, suggesting it could be developed into a new cancer treatment with fewer side effects.

Research Keyword: Hirshfeld surface analysis

Identification of two novel thiazolidin-2-imines as tyrosinase inhibitors: synthesis, crystal structure, molecular docking and DFT studies

Acetophenone-Based 3,4-Dihydropyrimidine-2(1H)-Thione as Potential Inhibitor of Tyrosinase and Ribonucleotide Reductase: Facile Synthesis, Crystal Structure, In-Vitro and In-Silico Investigations