Research Keyword: high-fat diet

Inonotus hispidus Protects against Hyperlipidemia by Inhibiting Oxidative Stress and Inflammation through Nrf2/NF-κB Signaling in High Fat Diet Fed Mice

Inonotus hispidus is an edible mushroom that may help treat obesity and high cholesterol by reducing fat levels and inflammation in the body. In mice fed a high-fat diet, the mushroom improved cholesterol profiles, reduced liver damage, and promoted beneficial gut bacteria. The beneficial effects appear to work through activating the body’s natural antioxidant defenses and reducing inflammation-causing proteins.

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Antrodia Camphorata Supplement in the Early Life Inhibits Intestinal Tumorigenesis Later in Young Adult APC1638N Mice

Researchers found that a mushroom supplement called Antrodia camphorate, when given to mice during childhood and adolescence, helped prevent intestinal tumors when the mice reached young adulthood. This effect was especially strong in mice that ate a high-fat diet early in life. The supplement appears to work by reducing inflammation and blocking certain proteins involved in tumor growth.

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Anti-Obesity Effect of Chitoglucan in High-Fat-Induced Obesity Mice

A natural compound called chitoglucan extracted from enoki mushrooms (Flammulina velutipes) was found to reduce weight gain and body fat in mice fed a high-fat diet. The treatment worked by lowering levels of hormones called leptin and resistin that are elevated in obesity. This suggests that chitoglucan from enoki mushrooms could potentially help treat obesity and related metabolic disorders in humans.

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