Research Keyword: Hi-C

The genome sequence of the Oak Polypore, Buglossoporus quercinus (Schrad.) Kotl. & Pouzar

Scientists have completed a full genetic map of the oak polypore, a rare and threatened mushroom that only grows on ancient oak trees. This mushroom is protected by law in the UK because it is becoming increasingly rare due to habitat loss and isolation. The detailed genetic blueprint will help scientists develop better strategies to protect and restore populations of this important forest fungus, potentially through carefully planned translocation programs.

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Identification of a psychiatric risk gene NISCH at 3p21.1 GWAS locus mediating dendritic spine morphogenesis and cognitive function

Researchers identified a gene called NISCH that increases the risk of schizophrenia and bipolar disorder. When this gene is overactive, it changes the shape of connections between brain cells and impairs working memory in mice. Interestingly, blood pressure medications like clonidine can reduce NISCH activity and improve cognitive function, suggesting these drugs might help psychiatric patients.

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