Research Keyword: Hepatic steatosis

Effect of Nutraceutical Supplementation and Mediterranean Hypocaloric Diet on Calculated Steatosis Indices and Inflammation: Clinical and In Vitro Evidences

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This research shows that taking a specialized supplement containing natural plant compounds along with eating a Mediterranean diet can significantly help people with fatty liver disease. The supplement works by reducing harmful stress molecules in liver cells and calming down inflammation. After three months of treatment, patients showed improved liver health markers, better cholesterol levels, and improved blood sugar control. The study demonstrates that combining diet and targeted supplements is more effective than diet changes alone.

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Interventions targeting the gut-liver axis: A potential treatment strategy for metabolic dysfunction-associated steatotic liver disease

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Your gut bacteria play a crucial role in liver health. When harmful bacteria build up in your gut, they can trigger liver inflammation and fat accumulation, leading to fatty liver disease. Researchers found that simple lifestyle changes like intermittent fasting, eating certain foods that feed good bacteria, and maintaining a healthy diet can restore healthy gut bacteria, strengthen your intestinal barrier, and reduce liver disease. This gut-focused approach could offer new ways to prevent and treat fatty liver disease beyond current treatments.

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The Active Components of Traditional Chinese Medicines Regulate the Multi-Target Signaling Pathways of Metabolic Dysfunction-Associated Fatty Liver Disease

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This comprehensive review examines how traditional Chinese medicine ingredients can treat fatty liver disease through multiple biological pathways simultaneously. Unlike conventional drugs that target a single pathway, TCM compounds address the complex, interconnected causes of the disease including fat accumulation, inflammation, and tissue damage. The research identifies dozens of effective herbal compounds and proposes a new framework for designing TCM treatments tailored to individual patient needs.

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Characterization of the gut mycobiome in patients with non-alcoholic fatty liver disease and correlations with serum metabolome

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This study examined fungi in the gut of people with fatty liver disease and found that certain fungal species are more common in diseased patients. By analyzing both gut fungi and blood chemicals, researchers discovered that fungi significantly influence metabolic substances related to liver health. A computer model combining information about gut fungi and bacteria could identify fatty liver disease with reasonable accuracy, suggesting that fungi could be useful for disease diagnosis and potential treatment.

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Novel Approaches in Glucose and Lipid Metabolism Disorder Therapy: Targeting the Gut Microbiota–Bile Acid Axis

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Your gut bacteria play a key role in how your body manages blood sugar and fats, working through molecules called bile acids. Researchers have discovered that certain foods, supplements, and herbs can improve this gut bacteria-bile acid interaction to help prevent or treat diabetes and obesity. This review explains how these natural interventions work and suggests promising new ways to treat metabolic diseases by harnessing your gut health.

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The effect of chitosan supplementation on liver function, hepatic steatosis predictors, and metabolic indicators in adults with non-alcoholic fatty liver disease: a randomized, double-blinded, placebo-controlled, clinical trial

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This study tested whether taking chitosan supplements (a type of dietary fiber) helps people with fatty liver disease. Over 8 weeks, participants taking chitosan along with a calorie-reduced diet lost more weight, reduced their waist size, and showed improvement in liver enzyme levels compared to those taking placebo. However, the supplement did not significantly improve cholesterol, blood sugar, or other metabolic markers at the dose tested.

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