Research Keyword: GWAS

Natural expression variation for the Arabidopsis MED20a mediator complex subunit influences quantitative resistance to Sclerotinia sclerotiorum

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Scientists studied how different varieties of a common plant (Arabidopsis) naturally resist a destructive fungal disease caused by Sclerotinia sclerotiorum. By examining genetic differences among plant varieties and testing a fungus from different sources, they found that a gene called MED20a plays an important role in disease resistance. Plants with specific genetic variations in the MED20a gene’s control region were more resistant to infection.

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Identification of a psychiatric risk gene NISCH at 3p21.1 GWAS locus mediating dendritic spine morphogenesis and cognitive function

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Researchers identified a gene called NISCH that increases the risk of schizophrenia and bipolar disorder. When this gene is overactive, it changes the shape of connections between brain cells and impairs working memory in mice. Interestingly, blood pressure medications like clonidine can reduce NISCH activity and improve cognitive function, suggesting these drugs might help psychiatric patients.

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New approaches to tackle a rising problem: Large-scale methods to study antifungal resistance

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Fungal infections are becoming increasingly resistant to antifungal drugs, creating a serious public health challenge. Scientists are using advanced genetic sequencing and laboratory techniques to understand how fungi develop drug resistance and identify the specific genetic changes responsible. By cataloging resistance mutations and creating shared databases, researchers aim to develop better diagnostic tests and treatment strategies to combat these dangerous infections.

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