Research Keyword: gut mycobiome

Gut fungi are associated with human genetic variation and disease risk

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Researchers discovered for the first time how human genes influence the fungi living in our gut and how this connection affects heart disease risk. They found that a yeast called Kazachstania is regulated by a gene called CDH13, and people with certain genetic variants have less of this beneficial yeast and higher risk of heart disease. This groundbreaking study shows that our genetics don’t just affect bacteria in our gut—they also shape our fungal community, which has real implications for heart health.

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Gut fungal profiles reveal phylosymbiosis and codiversification across humans and nonhuman primates

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Researchers studied fungal communities in the guts of humans and various primates to understand how these fungi evolved alongside their hosts. They discovered that more closely related primate species have more similar fungal communities, and that some fungi show signs of evolving together with primates over millions of years. These findings suggest that gut fungi are long-term partners with their hosts rather than temporary travelers from diet alone.

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Role of Candida species in pathogenesis, immune regulation, and prognostic tools for managing ulcerative colitis and Crohn’s disease

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This article explores how fungi, particularly Candida species, contribute to inflammatory bowel diseases like Crohn’s disease and ulcerative colitis. The fungal microbiota becomes imbalanced in IBD patients, triggering harmful immune responses and worsening inflammation. The researchers propose that measuring specific Candida levels could help doctors diagnose disease severity and predict treatment response, opening new possibilities for personalized IBD management.

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