Research Keyword: Gut dysbiosis

Gut-Brain Axis in Obesity: How Dietary Patterns Influence Psychological Well-Being and Metabolic Health

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This review explains how our diet affects both our gut bacteria and our mental health through the gut-brain axis, a communication system between our digestive system and brain. Mediterranean diets rich in fiber and healthy foods support beneficial bacteria and mental well-being, while Western diets high in processed foods harm gut health and increase obesity risk. Emotional eating driven by stress and depression worsens obesity, but targeted dietary interventions with prebiotics, probiotics, and fiber can help restore balance and improve both physical and mental health.

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The Role of Nutraceuticals and Probiotics in Addition to Lifestyle Intervention in the Management of Childhood Obesity—Part 1: Metabolic Changes

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This review examines how natural compounds and beneficial bacteria can help obese children improve their metabolic health when combined with diet and exercise changes. Key findings show that supplements like white mulberry leaf extract and special fiber products can help reduce weight, improve blood sugar control, and lower cholesterol. The evidence suggests these natural interventions are promising but need more large-scale studies in children to confirm their effectiveness and optimal dosing.

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Strain-specific effects of Desulfovibrio on neurodegeneration and oxidative stress in a Caenorhabditis elegans PD model

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This research shows that different strains of bacteria called Desulfovibrio have very different effects on brain health. When scientists exposed worms to six different strains, they found that environmental strains actually protected against Parkinson’s-like symptoms, while strains from human patients and animals caused more damage. The worms strongly preferred to eat the environmental strains, suggesting they could sense which bacteria were harmful. This highlights how the type of bacteria in our gut matters just as much as the total amount.

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Characterization of the gut mycobiome in patients with non-alcoholic fatty liver disease and correlations with serum metabolome

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This study examined fungi in the gut of people with fatty liver disease and found that certain fungal species are more common in diseased patients. By analyzing both gut fungi and blood chemicals, researchers discovered that fungi significantly influence metabolic substances related to liver health. A computer model combining information about gut fungi and bacteria could identify fatty liver disease with reasonable accuracy, suggesting that fungi could be useful for disease diagnosis and potential treatment.

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Cross-cohort microbiome-wide study reveals consistent alterations in the gut bacteriome, but not the gut mycobiome, in patients with hypertension

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Researchers analyzed gut bacteria and fungi in hypertensive patients compared to healthy people across two regions in China. They found that hypertensive patients have significant changes in their gut bacteria, particularly an overgrowth of harmful species like Clostridium and a decrease in beneficial bacteria. Interestingly, fungi in the gut showed minimal differences. These bacterial changes could potentially be used as early warning signs for hypertension and might become targets for new treatments.

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Characterization of the gut mycobiome in patients with non-alcoholic fatty liver disease and correlations with serum metabolome

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This research reveals that the types of fungi living in our gut are linked to fatty liver disease in ways we didn’t fully understand before. While researchers have long studied bacteria in our gut, they largely ignored fungi, which turns out to play an important role too. The study found that certain fungal species are more common in people with fatty liver disease, and these fungi influence the metabolites (chemical compounds) in the blood that affect liver health. By combining information about fungi, bacteria, and blood chemistry, scientists developed a test that could identify fatty liver disease with 77% accuracy, suggesting that looking at gut fungi could help doctors diagnose and treat this common liver condition.

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