Research Keyword: GPI-anchored proteins

Phospholipase PlcH is involved in the secretion of cell wall glycoproteins and contributes to the host immune response of Aspergillus fumigatus

Researchers discovered that an enzyme called PlcH helps a dangerous mold called Aspergillus fumigatus release protective proteins into its cell wall. These proteins help the fungus survive and evade the immune system. When scientists removed the gene for PlcH, the fungus became weaker and more vulnerable to both antifungal drugs and immune cells, suggesting PlcH could be a target for new antifungal treatments.

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