Research Keyword: glycolysis

Transcriptomic and metabolic profiling reveals adaptive mechanisms of Auricularia heimuer to temperature stress

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Researchers studied how a popular edible mushroom called black wood ear (Auricularia heimuer) adapts to different temperatures. They found that the mushroom grows best at 35°C but struggles at very cold (15°C) or extremely hot (45°C) temperatures. By analyzing the genes and chemicals produced by the mushroom at different temperatures, scientists discovered that the mushroom uses different survival strategies depending on how hot or cold it is, which could help farmers grow better mushrooms.

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Axin2 coupled excessive Wnt-glycolysis signaling mediates social defect in autism spectrum disorders

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Autism spectrum disorder affects social abilities in millions of people, but the underlying causes remain poorly understood. This research discovered that in the brains of people with autism, certain cellular processes that control energy and signaling become overactive, particularly in the region controlling social behavior. The good news is that the researchers found a drug-like compound called XAV939 can restore normal function by blocking the abnormal interaction between two key proteins, potentially offering a new treatment approach.

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Growth Phase-Dependent Changes in the Carbohydrate Metabolism of Penicillium Strains from Diverse Temperature Classes in Response to Cold Stress

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This study examined how three types of fungus respond to cold temperatures by measuring changes in their metabolic enzymes. Researchers exposed young and old fungal cells to cold stress and found that cold temperatures increased enzyme activity in both energy production pathways. Interestingly, the Antarctic psychrotolerant fungus adapted better to cold than the mesophilic fungi, showing that cold-adapted organisms have superior strategies for surviving freezing conditions.

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Immunometabolic reprogramming in macrophages infected with active and dormant Cryptococcus neoformans: differential modulation of respiration, glycolysis, and fatty acid utilization

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Researchers discovered that when fungal yeast cells enter a dormant state inside immune cells, they trigger different metabolic changes compared to actively growing yeast. While active yeast pushes immune cells to work harder metabolically, dormant yeast causes minimal stress but increases fat uptake by immune cells. This difference may explain how some fungal infections can remain hidden in the body for long periods without causing symptoms.

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Growth Phase-Dependent Changes in the Carbohydrate Metabolism of Penicillium Strains from Diverse Temperature Classes in Response to Cold Stress

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This study examined how different fungal strains from cold and warm environments respond to sudden temperature drops. Researchers tracked enzyme activity related to energy production and found that fungi adapted to cold environments handle stress better than warmth-loving fungi. The type of enzyme activity and how old the fungal cells were both affected the response to cold, providing insights that could help predict how disease-causing fungi behave in cold conditions.

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Immunometabolic reprogramming in macrophages infected with active and dormant Cryptococcus neoformans: differential modulation of respiration, glycolysis, and fatty acid utilization

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This research examines how immune cells (macrophages) respond differently to active versus dormant forms of a dangerous fungus called Cryptococcus neoformans. The dormant form causes the immune cells to accumulate fatty acids differently than the active fungus, which may help the fungus establish long-term infections. Understanding these differences could lead to better treatments for cryptococcal infections, which are particularly dangerous for immunocompromised individuals.

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