Research Keyword: glutathione metabolism

Educational Case: Acetaminophen hepatotoxicity: Pathophysiology and evaluation of acute liver failure

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This educational case describes how acetaminophen overdose causes severe liver damage leading to acute liver failure. The toxic form of acetaminophen damages liver cell mitochondria and causes widespread cell death, particularly in the center of liver lobules. Treatment with N-acetylcysteine within 24 hours of overdose significantly improves outcomes, though severe cases require liver transplantation.

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Enhanced Heat Resistance in Morchella eximia by Atmospheric and Room Temperature Plasma

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Researchers used a special plasma technology to create heat-resistant strains of morel mushrooms that can thrive at higher temperatures. These mutant strains showed enhanced natural defense systems with more antioxidant enzymes and protective compounds. This breakthrough could help farmers grow more morels successfully despite rising temperatures from climate change, while maintaining their nutritional and medicinal benefits.

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Skin Improvement with Antioxidant Effect of Yuja (Citrus junos) Peel Fractions: Wrinkles, Moisturizing, and Whitening

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Yuja, a citrus fruit traditionally used in Asian medicine, shows promising benefits for skin health. This study found that extracts from Yuja peels can help reduce wrinkles, improve skin moisture, and lighten dark spots by protecting skin cells from UV damage and reducing harmful free radicals. The effects work through natural mechanisms that boost collagen production and inhibit melanin overproduction, making Yuja peel fractions promising ingredients for new skincare products.

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Tolerance and antioxidant response to heavy metals are differentially activated in Trichoderma asperellum and Trichoderma longibrachiatum

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This research examined how two types of fungi called Trichoderma respond to contamination from heavy metals like copper, lead, and chromium. The study found that one species (T. longibrachiatum) is better at surviving heavy metal exposure than the other. Both species activate defensive mechanisms to combat the toxic effects, including producing protective proteins and enzymes that neutralize harmful molecules called reactive oxygen species.

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