Research Keyword: genetic stability

Effects of mating-type ratio imbalance on the degeneration of Cordyceps militaris subculture and preventative measures

Cordyceps militaris is a medicinal fungus used in traditional Chinese medicine that has healing properties but degenerates quickly when repeatedly cultured in laboratories. This research found that the loss of genetic mating-type information during subculturing is the main cause of this degeneration. By separately culturing different genetic types and mixing them before production, or by using stable single genetic-type strains, farmers can maintain consistent quality fruiting bodies for harvest and medicinal use.

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Strongest untreated mycelium materials produced by Schizophyllum commune dikaryons

Researchers found that mushroom mycelium grown from dikaryotic strains (with two nuclei) produces stronger, stiffer materials than traditional monokaryon strains used in mycelium-based products. These dikaryotic materials show tensile strength values comparable to some polymers, making them promising for creating sustainable alternatives to leather and textiles. The improved strength comes from differences in cell wall composition and lower expression of a hydrophobin gene, offering new possibilities for bio-based material development.

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Enhancement of Perylenequinonoid Compounds Production from Strain of Pseudoshiraia conidialis by UV-Induced Mutagenesis

Researchers used UV light to mutate fungal strains that naturally produce powerful medicinal compounds called perylenequinones. These compounds show promise for treating cancer and viral infections through photodynamic therapy. Through careful mutagenesis and screening, they developed a superior fungal strain that produces over 2100 mg/L of these valuable compounds, far exceeding previous methods. The breakthrough highlights that focusing on multiple beneficial compounds rather than just one can lead to better commercial applications.

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