Research Keyword: genetic mutations

The phenomenon of strain degeneration in biotechnologically relevant fungi

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Fungi used in industries to produce antibiotics, enzymes, and other useful products sometimes mysteriously lose their ability to produce these substances effectively. This review explains why this happens through various mechanisms including genetic changes, chemical modifications of genes, and stress responses. The authors provide practical strategies to prevent this loss of productivity, such as careful strain selection, proper storage methods, and tailored bioprocess design to maintain stable production.

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Genetic and Genomic Analysis Identifies bcltf1 as the Transcription Factor Coding Gene Mutated in Field Isolate Bc116, Deficient in Light Responses, Differentiation and Pathogenicity in Botrytis cinerea

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Scientists identified the genetic mutation responsible for unusual traits in a fungal strain (Bc116) that causes grape disease. The mutation in the bcltf1 gene prevents the fungus from infecting plants when exposed to light, while making it produce excessive spores and form smaller seed structures. By restoring the normal gene in laboratory experiments, researchers confirmed that this single gene controls multiple important fungal behaviors related to light sensing and disease-causing ability.

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Comprehensive analysis of the mechanisms conferring resistance to phenamacril in the Fusarium species

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Fusarium fungi cause serious diseases in crops like wheat, rice, and vegetables worldwide, leading to significant food losses and contamination with harmful toxins. Phenamacril is a modern fungicide designed to fight these fungi by targeting a specific protein called myosin-5. However, the fungi have developed resistance to this fungicide through genetic changes and other mechanisms, making it less effective over time. Farmers need to use multiple strategies including crop rotation and resistant plant varieties rather than relying only on fungicides to successfully manage these diseases.

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