Research Keyword: genetic drift

Misconception of Schizophyllum commune strain 20R-7-F01 origin from subseafloor sediments over 20 million years old

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Researchers questioned whether a fungus found in ancient ocean sediments 2 km below the seafloor actually came from 20 million years ago or was modern contamination. By analyzing DNA repetitive sequences in different fungal populations, they discovered the strain was genetically almost identical to modern fungi from Asia, not ancient at all. The extreme conditions in the deep sediments would make it impossible for fungi to survive or exchange genes for millions of years, proving the fungus came from surface contamination during drilling rather than ancient times.

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Unlocking the potential of experimental evolution to study drug resistance in pathogenic fungi

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Fungal infections are becoming harder to treat as fungi develop resistance to antifungal drugs. This review explains how scientists can use experimental evolution—growing fungi in controlled laboratory conditions while exposing them to drugs—to understand how and why resistance develops. By studying these evolutionary processes and using mathematical models to predict outcomes, researchers can develop better treatment strategies, including combination therapies and drug cycling approaches to prevent resistance from emerging.

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