Researchers are exploring mRNA vaccines, similar to those used for COVID-19, as a new approach to prevent fungal infections. These vaccines use fatty particles called lipid nanoparticles to deliver instructions to cells on how to make fungal proteins, triggering an immune response. The review discusses how to optimize these vaccines, what challenges need to be overcome, and why they might be especially useful for people with weakened immune systems who are most vulnerable to serious fungal infections.