Research Keyword: gene overexpression

Mechanism Underlying Ganoderma lucidum Polysaccharide Biosynthesis Regulation by the β-1,3-Glucosyltransferase Gene gl20535

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Researchers studied a gene called gl20535 in the medicinal mushroom Ganoderma lucidum that controls how the fungus makes beneficial polysaccharides. When they increased this gene’s activity, the mushroom produced significantly more polysaccharides with improved composition. The gene works by controlling sugar pathways and related enzyme production, and the mushroom compensates when this gene is reduced. These findings could help improve the production of medicinal mushroom products for food and health applications.

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Lentinan inhibits colorectal cancer stemness by binding CD133 and suppressing the CD133/p85/p-AKT signaling axis

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Researchers discovered that lentinan, a natural compound from shiitake mushrooms, can specifically target and kill cancer stem cells in colorectal cancer by binding to a protein called CD133. This is significant because cancer stem cells are the reason why cancers come back even after treatment. By blocking a specific pathway these cells use to survive, lentinan may help prevent cancer recurrence and reduce the side effects associated with traditional chemotherapy.

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Construction of a heat-resistant strain of Lentinus edodes by fungal Hsp20 protein overexpression and genetic transformation

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Scientists successfully created a heat-resistant version of shiitake mushrooms by adding extra copies of a heat-protection gene from button mushrooms. The modified mushrooms can survive higher temperatures and recover better after heat stress compared to regular shiitake strains. This genetic improvement could help shiitake farming expand to warmer regions and times of year, potentially increasing production worldwide.

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Identification and functional analysis of the SET domain-containing gene family in Cordyceps militaris

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Researchers identified 22 genes in the medicinal fungus Cordyceps militaris that control how genetic information is accessed through histone modifications. By studying how these genes respond to salt and amino acid treatments, they found that two specific genes (CmSET14 and CmSET16) are linked to cordycepin production, a compound with potential anti-cancer properties. When these genes were enhanced in the fungus, cordycepin production increased significantly, offering a new strategy to boost production of this valuable medicinal compound.

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