Research Keyword: gene expression

Volatile Metabolome and Transcriptomic Analysis of Kosakonia cowanii Ch1 During Competitive Interaction with Sclerotium rolfsii Reveals New Biocontrol Insights

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Researchers studied how a beneficial bacterium called K. cowanii fights against a harmful soil fungus (S. rolfsii) that damages crops like chili peppers. The bacterium produces special smelly compounds (VOCs) that kill the fungus. When these compounds are present, the bacterium activates specific genes that help it produce substances to protect itself and inhibit fungal growth. This research could help farmers use natural biocontrol instead of chemical fungicides.

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Comparative Multi-Omics Analysis and Antitumor Activity of Phylloporia crataegi and Phylloporia fontanesiae

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Two species of medicinal fungi were studied to understand why one was better at fighting cancer cells. Researchers analyzed the chemicals, genes, and proteins in both fungi and found that Phylloporia crataegi had much higher levels of cancer-fighting compounds and activated special cellular defense pathways that harm cancer cells. This research shows that medicinal fungi could be promising sources for developing new cancer treatments.

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New insights into the stress response mechanisms of stress-resistant Listeria monocytogenes via multi-omics and cell morphological changes

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Researchers studied how a dangerous food-poisoning bacterium called Listeria monocytogenes survives in harsh conditions like cold temperatures, acidic environments, and salty food products. Using advanced molecular analysis techniques, they identified specific genes and proteins that help the bacteria survive these stressful conditions. They also observed that the bacteria changed shape when exposed to stress, becoming elongated and bumpy. This research helps food safety experts better understand and combat this persistent food contaminant.

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Comparative Multi-Omics Analysis and Antitumor Activity of Phylloporia crataegi and Phylloporia fontanesiae

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Researchers compared two types of medicinal fungi (Phylloporia crataegi and P. fontanesiae) to understand why one is more effective at fighting cancer. Using advanced molecular analysis techniques, they found that P. crataegi contains higher levels of cancer-fighting compounds and activates more genes related to cancer cell death. These findings suggest that these fungi could be promising sources for developing new cancer treatments.

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Immunometabolic reprogramming in macrophages infected with active and dormant Cryptococcus neoformans: differential modulation of respiration, glycolysis, and fatty acid utilization

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This research examines how immune cells (macrophages) respond differently to active versus dormant forms of a dangerous fungus called Cryptococcus neoformans. The dormant form causes the immune cells to accumulate fatty acids differently than the active fungus, which may help the fungus establish long-term infections. Understanding these differences could lead to better treatments for cryptococcal infections, which are particularly dangerous for immunocompromised individuals.

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