gene expression – Page 10

Impact of sublethal zinc exposure on ectomycorrhizal Laccaria bicolor x poplar symbiosis

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This research examines how a common fungus called Laccaria bicolor helps poplar trees survive in soil contaminated with zinc, a heavy metal. Even though the zinc slows down both the fungus and plant growth, they can still form a beneficial partnership. The study found that the fungus activates specific defense mechanisms to protect itself and the plant from zinc damage, particularly through the production of protective proteins and enzymes that reduce harmful chemical reactions.

Transcriptomic Profiling of Thermotolerant Sarcomyxa edulis PQ650759 Reveals the Key Genes and Pathways During Fruiting Body Formation

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Researchers studied how a special strain of Sarcomyxa edulis (a tasty edible mushroom from Northeast China) develops fruiting bodies by analyzing which genes are turned on and off during this process. By comparing immature mycelium with developing fruiting bodies, they identified key genes responsible for cell division, DNA repair, and energy metabolism that control fruiting body formation. This knowledge can help mushroom farmers improve yield and quality through better understanding of how mushrooms grow. The findings provide a foundation for developing better cultivation techniques and selecting superior mushroom strains for commercial production.

Multi-omics analysis of Taiwanofungus gaoligongensis: effects of different cultivation methods on secondary metabolites

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Scientists studied a medicinal mushroom species to understand how different growing methods affect its beneficial compounds. They found that growing the mushroom on specific wood substrates (from cinnamon trees) produced much higher levels of therapeutic compounds compared to rice-based cultivation. Using advanced molecular techniques, they identified the genes responsible for producing these medicinal compounds and how they are controlled, providing insights to improve mushroom cultivation for better health benefits.

Integrated Transcriptomic and Proteomic Analyses Reveal Molecular Mechanism of Response to Heat Shock in Morchella sextelata

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Morels are delicious edible mushrooms, but growing them is challenging when temperatures get too high. Scientists studied two morel strains to understand how they respond to heat stress by examining their genes and proteins. They found that heat-tolerant strains activate special protective proteins and metabolic pathways, with one strain particularly good at activating a protein called Rsp5 that helps other protective proteins work better. These findings could help farmers grow better morels even as climate change makes temperatures warmer.

The expression of fungal CotH, human glucose-regulated protein 78 (GRP78), and predicted miRNAs in macrophages and diabetic mice infected with Rhizopus oryzae

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Mucormycosis is a serious fungal infection caused by Rhizopus oryzae that is particularly dangerous for people with diabetes. This study shows that a fungal protein called CotH3 attaches to a human cell receptor called GRP78, allowing the fungus to invade cells more easily in diabetic patients. The research found that diabetes increases GRP78 production, making fungal invasion more likely, while antifungal treatment (liposomal amphotericin B) can reduce the expression of both CotH3 and GRP78.

Study of the antagonistic relationship between gene expression biofilm of Aspergillus niger and Staphylococcus aureus that cause otomycosis

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Researchers studied how bacteria (S. aureus) and fungi (A. niger) interact when both infect the ear canal, a condition called otomycosis. They found that bacteria significantly suppress the fungus’s ability to form protective biofilms by reducing the expression of genes needed for fungal growth. This antagonistic relationship suggests that mixed infections might actually be easier to treat than pure fungal infections, offering new insights for managing ear infections.

Integrated Transcriptomic and Proteomic Analyses Reveal Molecular Mechanism of Response to Heat Shock in Morchella sextelata

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Morels are delicious mushrooms that are difficult to grow because they are very sensitive to high temperatures. Scientists compared two different morel strains to understand why one variety can tolerate heat better than the other. By studying the genes and proteins expressed at normal and high temperatures, researchers discovered that the heat-tolerant strain activates specific protective mechanisms, particularly through a protein called Rsp5 that helps boost other protective proteins. This research provides valuable information for breeding morel varieties that can survive warmer growing conditions in the age of climate change.

The putative forkhead transcription factor FhpA is necessary for development, aflatoxin production, and stress response in Aspergillus flavus

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Aspergillus flavus is a fungus that contaminates crops and produces aflatoxins, dangerous toxins that can harm human health and reduce crop value. Scientists studied a specific regulatory gene called fhpA that controls how this fungus develops and produces aflatoxins. They found that removing this gene causes the fungus to produce more aflatoxins and more spores but lose the ability to form protective sclerotial structures, suggesting this gene could be a target for controlling aflatoxin contamination in foods.

Ex Vivo Host Transcriptomics During Cryptococcus neoformans, Cryptococcus gattii, and Candida albicans Infection of Peripheral Blood Mononuclear Cells From South African Volunteers

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Researchers studied how human immune cells respond to three different fungal infections that commonly affect people with weakened immune systems. By examining gene activity in blood cells exposed to these fungi, they discovered that each fungus triggers different immune responses, with Candida albicans causing a much stronger reaction than the two Cryptococcus species. Only one shared immune pathway was activated by all three fungi, suggesting each infection requires different immune mechanisms to fight off. These findings could help develop new treatments for serious fungal infections.

Comparative transcriptome analysis reveals the genetic basis underlying the biosynthesis of polysaccharides in Hericium erinaceus

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Researchers studied six different strains of lion’s mane mushrooms to understand how they produce beneficial compounds called polysaccharides. Using advanced genetic analysis, they identified thirteen key genes responsible for making these health-promoting molecules. The study found that a strain called PZH-05 produced the most polysaccharides, and its genes were more active than in other strains. This research helps explain why lion’s mane mushrooms are effective for boosting immunity, fighting cancer, and managing blood sugar.

Research Keyword: gene expression