Research Keyword: gene expression modulation

Seagrass Enhalus acoroides extract mitigates obesity and diabetes via GLP-1, PPARγ, SREBP-1c modulation and gut microbiome restoration in diabetic zebrafish

Researchers tested a seagrass extract called Enhalus acoroides on diabetic zebrafish and found it effectively reduced body weight and blood sugar levels, performing as well or better than metformin, a common diabetes medication. The extract worked by activating genes that promote glucose metabolism and reducing genes that promote fat storage. Importantly, the extract also restored healthy gut bacteria balance, which appears to play a key role in its therapeutic effects. These findings suggest that seagrass could be developed into a natural supplement or functional food to help treat obesity and diabetes.

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Interference with sexual mating of Sporisorium scitamineum by verrucarin A isolated from Paramyrothecium sp

Scientists discovered a fungus called Paramyrothecium that produces a natural compound called verrucarin A, which stops sugarcane smut disease by preventing infected fungus cells from mating with each other. In greenhouse experiments, using this compound reduced disease symptoms from 80% infection down to 37%, and it didn’t harm the sugarcane plants. This provides a safe, natural way to control an important crop disease without using chemical pesticides.

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