Research Keyword: gene deletion

The phenol-2-monooxygenase FgPhm1 regulates DON synthesis, pathogenicity and environmental stress response in Fusarium graminearum

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Researchers studied a fungal protein called FgPhm1 in a wheat-infecting fungus that produces harmful toxins called DON. By deleting this gene, they found that the fungus became unable to infect plants and produce toxins, making it less dangerous. The protein also helps the fungus handle stress conditions, and removing it makes the fungus sensitive to oxidative stress while paradoxically tolerant to phenol.

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CBC Complex Regulates Hyphal Growth, Sclerotial Quantity, and Pathogenicity in the Necrotrophic Fungus Botrytis cinerea

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Scientists studied how two proteins (BcCbp20 and BcCbp80) work together in gray mold fungus, which destroys crops worldwide. These proteins control how the fungus grows, makes spores, forms long-term survival structures, and causes disease. The findings show that BcCbp80 is more important for growth and infection, while BcCbp20 helps the fungus survive stress. Understanding these proteins could help develop new antifungal treatments.

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Essential role of sugar transporters BbStp13 in fungal virulence, conidiation, and cell wall integrity in entomopathogenic fungus Beauveria bassiana

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Scientists studied a fungal protein called BbStp13 that helps a beneficial fungus called Beauveria bassiana attack insect pests. When this protein was removed, the fungus produced fewer spores and couldn’t infect insects as effectively, especially when sugar was scarce. The protein also helps the fungus protect itself from the insect’s immune system. Understanding this protein could help make the fungus better at pest control.

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SUB6 Subtilisin is Involved During the Initial Adhesion of Trichophyton benhamiae and T. mentagrophytes onto Reconstructed Human Epidermis

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Researchers studied a fungal protease called SUB6 produced by common skin infection-causing fungi. Using engineered fungi lacking this protein, they found that SUB6 helps fungi initially stick to skin but isn’t absolutely required for infection. The fungi can compensate by producing other proteases, suggesting SUB6 might be better used as a diagnostic marker to detect fungal infections rather than as a drug target.

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Essential role of sugar transporters BbStp13 in fungal virulence, conidiation, and cell wall integrity in entomopathogenic fungus Beauveria bassiana

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Researchers studied a fungus called Beauveria bassiana that is used to control insect pests. They found that a protein called BbStp13, which helps the fungus absorb sugars, is crucial for the fungus to infect insects effectively and make spores for spreading. When they removed this protein, the fungus became less dangerous to pests and couldn’t reproduce as well, especially when there wasn’t much food available. These findings could help make this natural pest control method even better.

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Transcription factor RonA-driven GlcNAc catabolism is essential for growth, cell wall integrity, and pathogenicity in Aspergillus fumigatus

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Researchers identified how a deadly fungus called Aspergillus fumigatus uses a special nutrient (GlcNAc) to survive and cause disease. They found that a protein called RonA controls this nutrient processing and also helps the fungus hide from the immune system by building a protective outer coating. When RonA is disabled, the fungus becomes much less dangerous because the immune system can recognize it better. This discovery suggests RonA could be a new target for developing antifungal drugs.

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The Kelch Repeat Protein VdKeR1 Is Essential for Development, Ergosterol Metabolism, and Virulence in Verticillium dahliae

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Verticillium dahliae is a serious fungal disease that kills many important crops like cotton and tomato by clogging their water-conducting vessels. Scientists discovered a protein called VdKeR1 that helps this fungus grow and cause disease by controlling how it makes ergosterol, a crucial component of fungal cell membranes. When researchers removed this protein, the fungus grew poorly, couldn’t form survival structures, and was much less dangerous to plants.

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