Research Keyword: Fusarium

Identification of an antifungal lipopeptide from Bacillus amyloliquefaciens HAU3 inhibiting the growth of Fusarium graminearum using preparative chromatography and 2D-NMR

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Scientists discovered a beneficial soil bacterium called Bacillus amyloliquefaciens that produces a natural antifungal compound called fengycin, which effectively kills dangerous mold (Fusarium graminearum) that contaminates animal feed. This bacterium can be used as a biological control agent to prevent fungal growth and reduce harmful mycotoxins in livestock feed, offering a safer and more environmentally friendly alternative to chemical fungicides. The study shows the bacterium’s compounds damage fungal cell membranes and generate harmful stress molecules that kill the fungus.

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Olorofim activity against multidrug-resistant Fusarium unveils intra-species and inter-species variability

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Researchers tested a new antifungal drug called olorofim against 253 different Fusarium fungi that infect humans. Fusarium is particularly dangerous for people with weakened immune systems and resists most common antifungals. The study found that olorofim works, but its effectiveness varies significantly depending on which type of Fusarium is present. While these lab results are promising, additional testing in animal models is needed before it can be used clinically.

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Inhibition of RNase to Attenuate Fungal-Manipulated Rhizosphere Microbiome and Diseases

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A fungal pathogen that causes root rot in soybeans and other crops uses a toxic protein called Fg12 to kill beneficial bacteria in the soil that would otherwise protect plants. Scientists discovered that guanosine monophosphate (GMP), a simple chemical compound, can block this toxic protein. When applied to soil, GMP protects plants by allowing beneficial bacteria to survive and fight the fungal infection.

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Effect of Popcorn (Zea mays var. everta) Popping Mode (Microwave, Hot Oil, and Hot Air) on Fumonisins and Deoxynivalenol Contamination Levels

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This study examined how different popping methods affect harmful toxins (called mycotoxins) in popcorn. Researchers tested 39 popcorn samples using three cooking methods: hot air, hot oil, and microwave, measuring how much the dangerous toxins fumonisins and deoxynivalenol decreased. They found that all three methods reduced toxin levels, with hot oil popping being the most effective, reducing fumonisins by 98% and deoxynivalenol by 58%. These findings suggest that eating properly prepared popcorn can significantly reduce exposure to naturally occurring toxins in corn.

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Unveiling the Substrate-Dependent Dynamics of Mycotoxin Production in Fusarium verticillioides Using an OSMAC-Metabolomics Approach

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Researchers studied how different growing conditions affect the production of harmful toxins by a fungus called Fusarium verticillioides that contaminates crops. Using advanced chemical analysis techniques, they found that the type of growth medium and time of incubation significantly influenced which toxins the fungus produced and in what amounts. Growing the fungus on corn-based medium produced different toxins than growing it on barley-based medium. These findings can help develop better strategies to prevent mycotoxin contamination in food and animal feed.

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Phylogenomic, Morphological, and Phylogenetic Evidence Reveals Five New Species and Two New Host Records of Nectriaceae (Hypocreales) from China

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Researchers identified five new species of fusarioid fungi (Fusarium and Neocosmospora) found in China by combining morphological observations with advanced genetic analysis of 4,941 genes. These fungi are important because they can be beneficial endophytes, harmless decomposers, or disease-causing pathogens. The study used modern genomic techniques to clearly distinguish between closely related species and confirmed fundamental differences between the two main genera. These findings will help scientists better identify and manage diseases caused by these fungi in agriculture and medicine.

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