Research Keyword: fungicidal activity

An implementation framework for evaluating the biocidal potential of essential oils in controlling Fusarium wilt in spinach: from in vitro to in planta

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Researchers tested four common essential oils (thyme, oregano, marjoram, and tea tree) to see if they could stop a dangerous fungal disease in spinach plants. They found that thyme and oregano oils worked best at killing the fungus in laboratory tests and when applied to spinach seeds in the greenhouse, with thyme oil reducing disease by over half without harming the plants.

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Antifungal Effects of Pterostilbene on Candida albicans, Candida dubliniensis, and Microcosm Biofilms of Denture Stomatitis

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Pterostilbene, a natural compound found in blueberries and grapes, has been shown to effectively kill Candida fungi that cause denture-related mouth infections. In laboratory tests, it successfully eliminated fungal cells and disrupted harmful biofilms within 8 hours. When tested in a living organism model, pterostilbene proved safe and reduced infection severity, suggesting it could be a promising natural alternative to conventional antifungal medications.

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Toward the consensus of definitions for the phenomena of antifungal tolerance and persistence in filamentous fungi

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Scientists have proposed clear definitions and testing methods for two drug-resistance phenomena in fungi that cause infections. Unlike typical drug resistance, tolerance and persistence allow fungi to survive antifungal medications but in different ways: tolerance affects most spores while persistence affects only a small fraction. By standardizing how these phenomena are tested using fungal spores and measuring how quickly drugs kill them, researchers can better understand treatment failures and develop better therapies.

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Localization of Secondary Metabolites in Relict Gymnosperms of the Genus Sequoia In Vivo and in Cell Cultures In Vitro, and the Biological Activity of Their Extracts

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Researchers studied an ancient giant redwood tree species to extract valuable medicinal compounds. They successfully grew Sequoia cells in laboratory culture that produced powerful cancer-fighting and antifungal substances. These extracts showed promise against cervical cancer and brain tumor cells while being safe to normal cells, offering a sustainable way to harvest these compounds without damaging wild redwood populations.

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HIV protease inhibitors restore amphotericin B activity against Candida

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Researchers discovered that HIV protease inhibitors, medications commonly used to treat HIV, can significantly enhance the effectiveness of amphotericin B, a powerful antifungal drug. When combined, these medications work synergistically to kill the dangerous fungus Candida auris, reduce its ability to form protective biofilms, and lower infection levels. This finding suggests a promising new treatment strategy for multidrug-resistant fungal infections that currently pose a serious global health threat.

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Impact of Various Essential Oils on the Development of Pathogens of the Fusarium Genus and on Health and Germination Parameters of Winter Wheat and Maize

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Researchers tested whether essential oils from common herbs like thyme, sage, and cumin could protect wheat and corn seeds from fungal diseases. Thyme oil worked best at killing the harmful fungi, but it also slowed down seed sprouting. The study suggests these natural oils could replace chemical fungicides in farming, though farmers need to carefully choose which oil and how much to use.

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