fungal stress response

Nitric Oxide-Mediated Regulation of Chitinase Activity and Cadmium Sequestration in the Response of Schizophyllum commune to Cadmium Stress

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Schizophyllum commune is an edible mushroom with health benefits, but cadmium pollution threatens both the fungus and human health. Researchers discovered that when exposed to cadmium, the mushroom produces a signaling molecule called nitric oxide that makes its cell wall enzymes more active, causing cadmium to accumulate in the cell wall and damaging the fungus. By controlling nitric oxide levels, scientists could potentially make these fungi more resistant to heavy metal pollution and safer for consumption.

Evaluation of the combined efficacy of inhibitors of heat shock protein 90 and calcineurin with commonly used antifungals against Aspergillus, Rhizopus, and Fusarium isolates

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Scientists tested combinations of common antifungal medications with special inhibitor drugs that target fungal stress-response systems. When combined, these drugs worked better together against dangerous mold infections like Aspergillus and Rhizopus, especially those that are resistant to standard treatments. The combinations rarely caused harmful interactions and often enhanced the antifungal effects, suggesting this approach could improve treatment of serious mold infections.

A Zn2-Cys6 transcription factor, TgZct4, reprograms antioxidant activity in the fungus Trichoderma guizhouense to defend against oxidative stress

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Trichoderma guizhouense is a fungus used to protect plants from harmful pathogens. Researchers discovered that a special protein called TgZct4 acts like a master switch that activates the fungus’s defense system against harmful reactive oxygen molecules. When the fungus encounters stress, TgZct4 turns on genes that produce protective enzymes called catalases and superoxide dismutases, helping the fungus survive. This discovery could help scientists create even more effective biological pest control products.

Research Keyword: fungal stress response

Nitric Oxide-Mediated Regulation of Chitinase Activity and Cadmium Sequestration in the Response of Schizophyllum commune to Cadmium Stress

Evaluation of the combined efficacy of inhibitors of heat shock protein 90 and calcineurin with commonly used antifungals against Aspergillus, Rhizopus, and Fusarium isolates

A Zn2-Cys6 transcription factor, TgZct4, reprograms antioxidant activity in the fungus Trichoderma guizhouense to defend against oxidative stress