Research Keyword: fungal resistance

A Case of Superficial Mycoses in a Patient with Systemic Lupus Erythematosus

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A 52-year-old woman with lupus developed severe fungal skin infections that were initially mistaken for worsening lupus symptoms. Her condition improved after 6 months of treatment with two antifungal medications (terbinafine and itraconazole). This case reminds doctors that patients taking immunosuppressive medications for lupus are at high risk for fungal infections, which can be misdiagnosed as lupus flares.

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Incidence and Risk Factors for Invasive Fungal Infection in Patients with Hematological Malignancies at a Tertiary Hospital in Malaysia

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This study examined fungal infections in cancer patients with blood disorders in a Malaysian hospital. Researchers found that about 7.6% of patients developed serious fungal infections, mainly from Candida species. Using antifungal medications to prevent infection significantly reduced the risk, though some patients still developed infections while taking preventive medications. The findings highlight the importance of appropriate antifungal treatment strategies in managing these vulnerable patients.

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Superhydrophobic Fatty Acid-Based Spray Coatings with Dual-Mode Antifungal Activity

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Researchers developed special water-repellent coatings made from natural fatty acids that can prevent fungal infections. These coatings work in two ways: they physically prevent fungi from sticking to surfaces through their bumpy structure, and they chemically kill fungi that do land on them. The coatings can be easily sprayed on like paint and offer an environmentally friendly alternative to traditional antifungal treatments that are becoming less effective.

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Molecular epidemiology, diversity, and antifungal susceptibility profiles of clinical and environmental mucorales: a five-year multicenter study in Iran (2018–2023)

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This study examined dangerous mold infections called mucormycosis that became more common during the COVID-19 pandemic, particularly in Iran. Researchers tested over 180 fungal samples from patients and soil to understand which types of molds cause infections and which antifungal medicines work best against them. They found that two medicines, amphotericin B and posaconazole, were most effective, while fungi from soil samples were often more resistant to treatment than those from infected patients. This research helps doctors choose the right treatments for patients with these serious infections.

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Invasive Candidiasis in Contexts of Armed Conflict, High Violence, and Forced Displacement in Latin America and the Caribbean (2005–2025)

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This comprehensive review examines candida fungal infections in conflict-affected areas of Latin America and the Caribbean, where wars, violence, and displacement create dangerous conditions that make infections more likely and harder to treat. In these regions, mortality from candida bloodstream infections reaches 65% or higher among displaced populations, compared to about 45-60% in regular hospitals. The main problems are lack of proper diagnostic equipment, limited access to effective antifungal medications, malnutrition, overcrowding in shelters, and the emergence of drug-resistant fungal strains.

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The role of Npt1 in regulating antifungal protein activity in filamentous fungi

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Researchers discovered how antifungal proteins work against a dangerous fungus (Aspergillus flavus) that damages crops and produces toxins. They found that these proteins break down the fungal cell wall and then interact with an internal fungal protein called Ntp1. By understanding exactly which part of Ntp1 the antifungal proteins bind to, scientists can now develop better treatments to protect food crops from fungal diseases.

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