fungal resistance – mycolab.ai

Chestnut Tannin/Furfuryl Alcohol Copolymers for Beech Wood Chemical Modification

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Researchers developed a new way to protect beech wood by combining natural tannins extracted from chestnut with furfuryl alcohol. This treatment makes the wood more resistant to rot-causing fungi while making it more water-resistant and thermally stable. The innovation is significant because it replaces half of the chemical compound (furfuryl alcohol) with a natural plant extract, making the wood treatment more sustainable and environmentally friendly.

Tracing the Origin and Evolution of the Fungal Mycophenolic Acid Biosynthesis Pathway

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Scientists studied how different mold species produce mycophenolic acid (MPA), a drug used to prevent transplant rejection in millions of patients worldwide. By examining the genomes of nearly 500 fungal species, they discovered which molds can make MPA and how they evolved this ability. The research found that MPA-producing fungi all have special resistance mechanisms to protect themselves from the toxic compound they produce, and these protection strategies differ between species.

Past, present and future of antifungals: Advancements in mechanisms of action and resistance

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Fungal infections are a growing global health threat, especially for people with weakened immune systems, causing millions of deaths annually. Currently available antifungal drugs are limited and increasingly face resistance, making them less effective over time. This special collection of research papers explores new approaches to treating fungal infections, including novel drugs, combination therapies, and alternative treatments to overcome resistance. Scientists and doctors hope these advances will help save more lives by providing better options for treating serious fungal diseases.

Plants, fungi, and antifungals: A little less talk, a little more action

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Plants and fungi communicate through small chemical molecules, and scientists are discovering that understanding this dialogue could lead to new antifungal medicines. Researchers found that a plant hormone called strigolactone affects a specific fungal protein involved in nutrient uptake, suggesting this could be a target for new drugs. By using baker’s yeast as a laboratory model, scientists can study how fungal cells respond to plant chemicals and identify new ways to fight dangerous fungal infections that are becoming resistant to current treatments.

Precision of Fungal Resistance Test Method for Cereal Husk-Reinforced Composite Construction Profiles Considering Mycelium Removal Techniques

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Scientists tested how well building materials made from plant husks and plastic resist fungal growth. They found that the standard testing method has serious accuracy problems, with results varying by more than 20%. They also discovered that how you clean the samples after fungal exposure significantly affects the test results, suggesting the test method needs better instructions.

Effect of AgNPs on PLA-Based Biocomposites with Polysaccharides: Biodegradability, Antibacterial Activity and Features

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Scientists created new eco-friendly plastic films made from corn-based PLA combined with natural starches and tiny silver particles. These films can break down in soil while also killing harmful bacteria, making them ideal for food packaging. The materials maintained good antibacterial properties even as they slowly degraded in the environment, showing promise as sustainable alternatives to conventional plastics.

Discovery of the antifungal compound ilicicolin K through genetic activation of the ilicicolin biosynthetic pathway in Trichoderma reesei

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Scientists used genetic engineering to activate a dormant gene cluster in the fungus Trichoderma reesei, enabling it to produce the antifungal compound ilicicolin H in high quantities. During this process, they discovered a new related compound called ilicicolin K that shows even stronger antifungal properties. These compounds could potentially overcome limitations of current antifungal treatments, especially against drug-resistant fungi like Candida auris.

Carabrone inhibits Gaeumannomyces tritici growth by targeting mitochondrial complex I and destabilizing NAD⁺/NADH homeostasis

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Researchers identified how carabrone, a natural compound from plants, kills a fungus that causes wheat disease. The compound works by blocking a key energy-producing system (complex I) inside the fungus’s cells, which prevents it from producing enough energy to survive. This discovery is important because many current fungicides are losing effectiveness due to resistance, and this compound offers a new way to attack fungi. The findings could help develop new and more effective fungicides for protecting crops.

A Method to Inoculate Millet Grain-Colonized Fusarium pseudograminearum on Wheat to Obtain Reproducible Disease Symptoms

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Researchers developed a reliable laboratory method to test wheat varieties for their ability to resist a serious fungal disease called crown rot caused by Fusarium pseudograminearum. Using millet grains colonized with the fungus as an inoculum, they can now consistently and quickly identify which wheat varieties are naturally resistant to the disease. This standardized method helps plant breeders efficiently select resistant wheat cultivars, reducing the need for chemical pesticides.

Precision of Fungal Resistance Test Method for Cereal Husk-Reinforced Composite Construction Profiles Considering Mycelium Removal Techniques

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Researchers tested how well different methods measure a composite material’s resistance to fungal attack. They found that the current testing method is not very reliable, with results varying significantly between tests. More importantly, they discovered that how you clean off the fungus after testing can significantly affect the results, suggesting that testing standards need to be improved and standardized.

Research Keyword: fungal resistance