fungal infection – Page 11

Recalcitrant dermatophytosis due to Trichophyton indotineae: A case series from Sarawak, Malaysia

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Three patients in Malaysia had persistent skin fungal infections caused by Trichophyton indotineae that did not respond to standard antifungal treatments. Genetic testing revealed these fungal strains carried a specific mutation making them resistant to terbinafine, the typical first-line treatment. While azole-based antifungals showed variable effectiveness depending on the specific drug and dose used, one patient achieved complete cure with voriconazole therapy. The study highlights the growing problem of drug-resistant fungal infections and the importance of targeted treatment based on laboratory testing.

Clinical Significance and Therapeutic Challenges of Scedosporium spp. and Lomentospora prolificans Isolates in a Single-Center Cohort of Lung Transplant Recipients

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This study examined dangerous fungal infections caused by Scedosporium and Lomentospora species in lung transplant patients at a Spanish hospital. Researchers found these infections were uncommon but very serious, with high death rates especially from the Lomentospora type. Current antifungal drugs often don’t work well against these fungi, highlighting the need for better treatment options.

Emergence of resistant dermatophytosis caused by Trichophyton indotineae: First case series in Thailand

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Researchers in Thailand have identified the first cases of a new resistant fungal skin infection caused by Trichophyton indotineae. This fungus is resistant to a commonly used antifungal drug called terbinafine and causes persistent skin rashes on various body parts. The study describes five patients whose infections were finally identified through genetic testing and who responded well to alternative antifungal treatment with itraconazole. This discovery suggests the fungus is now spreading in Thailand and doctors should watch for it.

Dermatophytosis in a Chilean fox: first case of Nannizzia gypsea in Lycalopex griseus and the need for a one health approach

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Researchers reported the first case of a fungal skin infection caused by Nannizzia gypsea in a wild South American grey fox found near Santiago, Chile. The fox developed crusted and scaly lesions on its tail, which were successfully treated with topical antifungal cream. This discovery highlights how increasing contact between domestic pets, wild animals, and humans due to urbanization can spread fungal infections, emphasizing the need for integrated health approaches that consider human, animal, and environmental health together.

Erythema Nodosum Associated with Kerion: A Case Series and Narrative Review of the Literature

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This paper describes a rare condition where patients develop painful red bumps on the shins (erythema nodosum) as a reaction to a severe scalp fungal infection (kerion) caused by Trichophyton mentagrophytes. The authors reviewed 23 similar cases and found that this reaction usually happens during antifungal treatment and resolves within about a week. Treatment with antifungal medications like griseofulvin, sometimes combined with anti-inflammatory steroids, is effective, though scarring of the scalp may remain.

Acidic pH Modulates Cell Wall and Melanization in Paracoccidioides brasiliensis, Affecting Macrophage Interaction

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A dangerous fungal infection called paracoccidioidomycosis affects people in Latin America. Researchers found that when this fungus encounters acidic conditions similar to those inside immune cells in the body, it protects itself by producing a dark pigment called melanin and changing its cell surface. These changes help the fungus hide from the immune system and reduce the ability of immune cells called macrophages to attack and destroy it.

Efficacy of Rezafungin on Candida albicans Endophthalmitis in a Rabbit Model

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Researchers tested a new antifungal drug called rezafungin against a serious eye infection caused by Candida fungus in rabbits. Rezafungin performed much better than two other commonly used antifungal drugs, completely eliminating the fungus from the eye while preventing infection-related damage. The drug’s ability to be given weekly instead of daily makes it more practical for treating patients with severe fungal eye infections.

Case Report: Aspergillosis and Cyathostoma americana co-infection in the lower respiratory tract of a Harris’s Hawk (Parabuteo unicinctus)

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A 12-year-old Harris’s Hawk died from a rare combination of two serious infections affecting its lungs and air sacs: a fungal infection (Aspergillus fumigatus) and a parasitic worm infection (Cyathostoma americana). This is the first documented case of these two infections occurring together in a hawk. The worms and fungus caused severe inflammation and tissue damage, ultimately leading to the bird’s death. This case highlights how multiple infections can work together to make disease more severe in captive birds of prey.

Draft genome sequences for four isolates of the hemp (Cannabis sativa) fungal pathogen Neofusicoccum parvum

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Scientists sequenced the complete genomes of four samples of a fungal disease that infects hemp plants. This fungus, called Neofusicoccum parvum, causes dying branches and damage to hemp crops. By mapping out the genetic code of these fungal samples, researchers now have important tools to better understand how this pathogen works and potentially develop strategies to protect hemp plants.

Rhino sinusitis caused by Lasiodiplodia theobromae in a diabetic patient

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A 56-year-old diabetic man developed a sinus infection caused by a rare fungus called Lasiodiplodia theobromae, which typically affects plants. The infection was diagnosed through laboratory testing and DNA sequencing, as traditional identification methods were inconclusive. The patient was successfully treated with a combination of sinus surgery and a six-week course of antifungal medication, showing complete recovery after one year of follow-up.

Research Keyword: fungal infection