fungal evolution – mycolab.ai

Cwh8 moonlights as a farnesyl pyrophosphate phosphatase and is essential for farnesol biosynthesis in Candida albicans

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Candida albicans is a common fungus that causes serious infections in people with weakened immune systems. The fungus produces a molecule called farnesol that prevents it from growing in long filaments, which are associated with virulence. Researchers discovered that an enzyme called Cwh8 is absolutely essential for making farnesol, and when this enzyme is missing, the fungus becomes highly sensitive to the antifungal drug fluconazole, suggesting a potential strategy to overcome drug resistance.

Horizontal gene cluster transfer increased hallucinogenic mushroom diversity

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Scientists discovered that distantly related hallucinogenic mushrooms produce psilocybin, the psychoactive compound in magic mushrooms, through a shared set of genes that were likely transferred between species living in similar environments like dung and decaying wood. By sequencing the genomes of three different hallucinogenic mushroom species, researchers found nearly identical gene clusters responsible for making psilocybin, and evidence showing these genes jumped between unrelated fungal lineages. This discovery suggests that fungi in dung and wood environments may be rich sources of other bioactive compounds with potential medical applications.

Tracing the Origin and Evolution of the Fungal Mycophenolic Acid Biosynthesis Pathway

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Scientists studied how different mold species produce mycophenolic acid (MPA), a drug used to prevent transplant rejection in millions of patients worldwide. By examining the genomes of nearly 500 fungal species, they discovered which molds can make MPA and how they evolved this ability. The research found that MPA-producing fungi all have special resistance mechanisms to protect themselves from the toxic compound they produce, and these protection strategies differ between species.

A new leaf inhabiting ascomycete from the Jurassic (ca 170 Mya) of Yorkshire, UK, and insights into the appearance and diversification of filamentous Ascomycota

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Scientists discovered and described a new ancient fungus called Harristroma eboracense that lived on plant leaves about 170 million years ago during the Jurassic period. This fungus helps us understand how fungi diversified and evolved over time. By studying this fossil and comparing it with modern fungi, researchers learned that fungi began developing specialized structures for infecting plants during the Mesozoic era, and that they likely first thrived on broad-leaved plants in warm, wet forests.

Genome assemblies for Pyricularia species and related genera isolated from diverse host plants

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Scientists have sequenced the complete genetic blueprints of 35 fungal strains belonging to Pyricularia species and related genera, which cause devastating blast diseases in crops like rice and wheat. By analyzing genetic differences between strains that infect different grass species, researchers found that most Pyricularia oryzae strains show strong preferences for specific host plants. These new genome resources will help scientists understand how fungal pathogens evolve and adapt to new plant hosts, potentially improving disease management strategies.

A timetree of Fungi dated with fossils and horizontal gene transfers

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Scientists created a detailed family tree of fungi showing when different fungal groups evolved, dating back up to 1.4 billion years ago. They used information from fossils, genes shared between distantly related fungi, and chemical evidence to figure out the timeline. The results suggest that fungi interacted with early algae ancestors of plants for a very long time before modern plants took over land.

Gene transfer between fungal species triggers repeated coffee wilt disease outbreaks

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A new study found that coffee wilt disease, which has caused major crop losses in Africa, has repeatedly emerged due to genes jumping between different fungal species. These genes travel via special mobile DNA elements called Starships, which act like genetic vehicles carrying pathogenic genes from one fungus to another. When Fusarium fungi exchanged genes this way, they became better at infecting different varieties of coffee plants. Understanding how these genes move is crucial for protecting coffee crops from future disease outbreaks.

MycoNews 2022: editorial, news, reports, awards, personalia, and book news

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Mycology is experiencing rapid growth in public awareness and scientific recognition. Popular books and films about fungi have dramatically increased interest in the field. The International Mycological Community celebrated major achievements in 2022, with prominent conferences and awards recognizing outstanding research and contributions to understanding fungi’s vital roles in nature and human health.

Blue-stain fungus from the Jurassic provides new insights into early evolution and ecological interactions

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Scientists discovered a fossilized blue-stain fungus from the Jurassic period in China, pushing back the earliest known record of these fungi by 80 million years. Blue-stain fungi are wood-colonizing organisms that cause discoloration in trees and can accelerate tree death when paired with wood-boring insects. This discovery reveals that these fungi and their relationships with insects evolved much earlier than previously thought, providing new understanding of ancient forest ecosystems and the evolution of fungal-insect interactions.

The protein kinases family in fungi: adaptability, virulence and conservation between species

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Protein kinases are cellular ‘switches’ that help fungi survive harsh conditions by regulating how cells make proteins and adapt to stress. A particularly important kinase called GCN2 acts as a sensor that detects when fungi lack amino acids, triggering a survival response that helps the fungus adapt and maintain pathogenicity. This review shows how understanding GCN2 could help scientists develop new antifungal drugs to treat fungal infections.

Research Keyword: fungal evolution