This study demonstrates that two types of fungi, Aspergillus flavus and Cunninghamella elegans, can effectively remove persistent pharmaceutical pollution from wastewater when grown as biofilms on foam carriers. The fungi achieved removal rates of 92-98% for three common medications (atorvastatin, ciprofloxacin, and fluoxetine) much faster than previously reported methods. Unlike traditional fungal treatments that depend on lignin, these fungi can work in diverse environments, making them practical for wastewater treatment plants and offering a sustainable biological solution to pharmaceutical pollution.