fluconazole resistance – Page 2

Synergistic potential and apoptosis induction of Bunium persicum essential oil and its pure components, cuminaldehyde and γ-terpinene, in combination with fluconazole on Candida albicans isolates: in vitro and in silico evaluation

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Researchers tested how Bunium persicum essential oil and its components work alongside the antifungal drug fluconazole against Candida albicans infections. Cuminaldehyde, a major component of the oil, showed the strongest effects when combined with fluconazole, making infection-causing cells die faster than each substance alone. This combination approach could help overcome drug-resistant fungal infections and offers a promising natural alternative to synthetic drugs alone.

Genomic Insights of Candida krusei, an Emerging Fungal Pathogen With Intrinsic Antifungal Resistance

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Candida krusei is a yeast that causes serious bloodstream infections, particularly in people with weakened immune systems. Unlike many other fungi, it naturally resists common antifungal drugs like fluconazole, making infections hard to treat. The organism can form protective biofilms and has multiple genetic mechanisms that help it survive antifungal treatment. Researchers are exploring new drugs and treatment strategies to combat this growing health threat, especially in hospitals.

Prevalence and antifungal susceptibility profiles of Candida isolates among patients with candiduria: a multiplex PCR assay

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Researchers studied yeast infections in urine from hospitalized patients using advanced molecular testing. They found that while Candida albicans was most common, other yeast species were becoming more resistant to antifungal medications. The study used a 21-tube PCR test to identify different yeast species and tested which medications worked best against them. Results showed that newer yeast species were much more likely to resist commonly used antifungal drugs like fluconazole.

Brown locusts, Locustana pardalina, host fluconazole-resistant Candidozyma (Candida) auris, closely related to Clade III clinical strains

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Scientists found that brown locusts in South Africa carry a dangerous yeast called Candida auris that is resistant to the antifungal drug fluconazole. This yeast is similar to strains that infect hospital patients and is highly adaptable, surviving extreme temperatures and salt levels found in locust guts. This discovery suggests that insects like locusts could play a role in spreading this emerging fungal pathogen in nature, which has important implications for understanding how dangerous microbes spread between animals and humans.

The Burden of Neonatal Invasive Candidiasis in Low- and Middle-income Countries: A Systematic Review and Meta-analysis

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This study examined fungal blood infections in newborns across low- and middle-income countries, analyzing data from nearly 11,000 cases. Researchers found these infections occur more frequently and have higher death rates in poorer countries compared to wealthy nations. They identified that most infections are caused by Candida fungus species, and many of these fungi have become resistant to fluconazole, the most commonly used treatment drug.

Antifungal activity and mechanism of novel peptide Glycine max antimicrobial peptide (GmAMP) against fluconazole-resistant Candida tropicalis

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Scientists developed a new antimicrobial peptide called GmAMP that can effectively kill drug-resistant fungal infections caused by Candida tropicalis, a pathogen resistant to common antifungal medications. The peptide works by damaging the fungal cell membrane and is safe for human use. In laboratory tests using insect larvae, the peptide successfully treated infections and reduced the fungal burden, suggesting it could become a new treatment option for patients with resistant fungal infections.

Acidic pH Reduces Fluconazole Susceptibility in Cryptococcus neoformans by Altering Iron Uptake and Enhancing Ergosterol Biosynthesis

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This research shows that acidic environments, like those found in inflamed tissues and inside immune cells, make the fungus Cryptococcus neoformans more resistant to the antifungal drug fluconazole. The fungus adapts to acidic conditions by using an alternative iron uptake system that increases the production of protective compounds (ergosterol) in its cell membrane. Understanding this pH-dependent resistance mechanism could help develop better treatment strategies for cryptococcal infections in patients with compromised immune systems.

Evaluation of Antifungal Activity Against Candida albicans Isolates From HIV-Positive Patients with Oral Candidiasis in a Major Referral Hospital, West Java, Indonesia

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Researchers in West Java, Indonesia studied fungal infections in the mouths of HIV-positive patients to understand which antifungals work best. They found that a common fungal species called Candida albicans was present in all patients tested, though some resistant strains were discovered. The study showed that certain antifungal medications like voriconazole worked better than others, highlighting the importance of testing which specific medications will be effective for each patient rather than guessing.

Antifungal susceptibility testing of Microsporum canis isolated from the skin of dermatologically healthy cats

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Researchers tested healthy cats in Chile and found that about 5% carried a fungus called Microsporum canis that can cause ringworm. This fungus was resistant to a common antifungal drug called fluconazole. Indoor cats were more likely to carry the fungus than outdoor cats. Because cats can spread this fungus to people, identifying carrier cats is important for preventing human infections.

Candida krusei Empyema: A Lung Transplant Case and Systematic Review of the Literature

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Candida krusei is a dangerous yeast that causes a serious lung infection called empyema, where pus collects around the lungs. This infection is particularly difficult to treat because the yeast is resistant to common antifungal drugs like fluconazole and can form protective biofilms. This systematic review identified only ten cases of this rare infection in the medical literature, showing how uncommon but serious it is, and found that patients need aggressive treatment with multiple antifungal medications combined with surgical drainage to survive.

Research Keyword: fluconazole resistance