fluconazole – mycolab.ai

Naganishia albidus Causing Perioral Cutaneous Infection: A Rare Case Easily Misdiagnosed

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A 37-year-old man developed an unusual fungal skin infection around his mouth caused by Naganishia albidus, a rare yeast. He was initially misdiagnosed with eczema and his condition worsened with wrong treatment. Advanced fungal testing techniques helped identify the correct organism, and after six weeks of antifungal medication (both oral and topical), his skin completely cleared. This case shows why doctors need to consider rare fungal infections when skin problems don’t respond to typical treatments.

The impact of osteoarticular invasion by Coccidioides Sp disseminated infection

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A 48-year-old man from Mexico developed a serious fungal infection caused by Coccidioides, which spread from his lungs to his skin, bones, and joints, causing pain and swelling. Despite having a normally functioning immune system, he developed progressive disease that was initially misdiagnosed as rheumatoid arthritis. After switching to the antifungal medication fluconazole, his condition improved dramatically, with symptoms resolving within several months of treatment.

A Case Report of Candidiasis Cellulitis in Long-Term Corticosteroid Use

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A 54-year-old man developed a serious skin infection on his hand caused by Candida, a normally harmless fungus, because he had been taking corticosteroid injections for 15 years for breathing problems. Despite antibiotic treatment, the swelling and pain continued. Doctors discovered it was a fungal infection through lab tests and treated it with antifungal medication (fluconazole) after draining the infection, which completely healed within two weeks.

Metabolic Patterns of Fluconazole Resistant and Susceptible Candida auris Clade V and I

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Researchers used advanced chemical analysis to identify different compounds produced by a dangerous fungus called Candida auris that can cause serious infections. They compared fungal strains that were resistant to the antifungal drug fluconazole with those that were susceptible, finding that resistant strains produced different metabolites (chemical compounds) than susceptible ones. These findings could help doctors develop better treatments by identifying what makes this fungus resistant to current medications.

Synergistic potential and apoptosis induction of Bunium persicum essential oil and its pure components, cuminaldehyde and γ-terpinene, in combination with fluconazole on Candida albicans isolates: in vitro and in silico evaluation

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Researchers studied how an essential oil from black cumin seeds (Bunium persicum) and two of its key active components could work together with the antifungal drug fluconazole to fight Candida albicans infections, including drug-resistant strains. Using laboratory tests and computer modeling, they found that cuminaldehyde, one of the main components, was particularly effective when combined with fluconazole, killing yeast cells through multiple mechanisms. This suggests that natural plant compounds could be valuable partners with conventional antifungal medications to overcome drug resistance.

Evaluation of Clinical, Microbiological Profiles and Management Patterns with Outcomes of Patients with Fungal Isolates in An Intensive Care Unit of A Tertiary Care Center: A Prospective Observational Study

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This study examined fungal infections in intensive care unit patients at a major hospital in India. Researchers found that diabetes was the most common risk factor, and most infections were caused by Candida species found in urine samples. Many fungal isolates were resistant to common antifungal drugs like fluconazole, suggesting doctors need to be more careful about which medications they use to treat these infections.

Randomized control trial to study the effectiveness of tablet Fluconazole, capsule Itraconazole and tablet Terbinafine in superficial dermatophytosis

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This study tested three common antifungal medications used to treat fungal skin infections like ringworm. The research involved 180 patients who were randomly given one of three drugs and then checked at 4 and 8 weeks to see if the infection was gone. Itraconazole worked best, clearing infections in about 87% of patients, followed by Fluconazole at 73%, and Terbinafine at 63%.

Deletion of RAP1 affects iron homeostasis, azole resistance, and virulence in Candida albicans

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Researchers found that a protein called Rap1 plays a critical role in how the dangerous fungus Candida albicans acquires and uses iron, which is essential for its survival in the human body. When the RAP1 gene was deleted, the fungus became much less virulent and lethal in infected mice, while paradoxically becoming more resistant to the antifungal drug fluconazole under iron-limited conditions. These findings suggest that targeting iron acquisition through Rap1 could be a new therapeutic strategy against serious fungal infections.

Characterizing antimicrobial activity of environmental Streptomyces spp. and oral bacterial and fungal isolates from Canis familiaris and Felis catus

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Researchers collected bacteria and fungi from the mouths of pet dogs and cats, as well as environmental soil bacteria, to search for natural antimicrobial compounds. They found that some of these microorganisms produce substances that can kill harmful bacteria like E. coli and fungi like Candida albicans, especially when combined with existing antifungal medications. Notably, one environmental bacterium (Streptomyces) produced a compound that was even effective against fungal strains resistant to common antifungal drugs, suggesting promising new treatment possibilities.

Antifungal efficacy of caffeic acid and nano-caffeic acid particles against candidiasis: an in vitro study

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Researchers developed a nano-particle form of caffeic acid, a natural compound found in coffee and tea, to treat oral yeast infections (candidiasis). The nano-version showed better antifungal activity than regular caffeic acid, though not as strong as prescription antifungal drugs. Since it comes from plants with fewer side effects, it could offer an alternative treatment option for patients with candidiasis.

Research Keyword: fluconazole