Research Keyword: fever

Atypical Adult-onset Still’s disease with flagellate morphology in a patient with skin of color

A 28-year-old African American woman was diagnosed with Adult-onset Still’s disease, a rare inflammatory condition causing fever, joint pain, and skin rashes. Her rash had an unusual linear, stripe-like pattern with dark pigmentation that doesn’t typically appear in standard descriptions of this disease. She was successfully treated with anakinra and later tocilizumab, medications that reduce inflammation, leading to complete symptom resolution and sustained improvement over nine months.

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Functional relationship between peripheral thermosensation and behavioral thermoregulation

This review explains how your body senses temperature through specialized proteins called TRP channels, which detect hot and cold stimuli. These temperature-sensing proteins help you and other animals regulate body temperature by triggering behaviors like seeking warmth or coolness. Importantly, the review shows that the fatty acid composition of cell membranes can fine-tune how sensitive these temperature sensors are, offering insights into how organisms adapt to different thermal environments.

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