evolutionary conservation

Structural and functional characterisation and regulatory mechanisms of SWI/SNF and RSC chromatin remodelling complexes in fungi

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This review examines two important protein complexes in fungal cells that help control which genes are turned on and off. These complexes, called SWI/SNF and RSC, use energy from ATP to move and adjust nucleosomes—the structures that package DNA. The researchers analyzed these complexes across different fungal species and found that while they share similar core components, fungi have evolved unique variations that allow them to survive and cause infections in different ways. Understanding how these complexes work could help scientists develop new antifungal drugs.

ELAV/Hu RNA-binding protein family: key regulators in neurological disorders, cancer, and other diseases

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ELAV/Hu proteins are molecular machines that control how cells read and use genetic instructions. Found mostly in the brain and nervous system, these proteins help manage which genes get turned on or off, which is crucial for proper brain development and function. When these proteins go wrong, they can contribute to serious diseases like Alzheimer’s, Parkinson’s, cancer, and autism, making them promising targets for new treatments.

Research Keyword: evolutionary conservation

Structural and functional characterisation and regulatory mechanisms of SWI/SNF and RSC chromatin remodelling complexes in fungi

ELAV/Hu RNA-binding protein family: key regulators in neurological disorders, cancer, and other diseases