Research Keyword: ergothioneine

A Review of Novel Antioxidant Ergothioneine: Biosynthesis Pathways, Production, Function and Food Applications

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Ergothioneine is a powerful natural antioxidant found mainly in mushrooms that protects cells from damage and may help prevent diseases like Alzheimer’s and heart disease. Currently, producing ergothioneine from mushrooms is expensive and slow, but scientists have developed faster fermentation methods using engineered microbes that could make it cheaper and more available. This compound can be added to foods and supplements to boost health benefits, and researchers are exploring its use beyond seafood to other food products like meat and baked goods.

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Ergothioneine: An Antioxidative, Neuroprotective and Anti-Inflammatory Compound from Mushroom Residuals

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Ergothioneine is a powerful antioxidant found mainly in mushrooms that protects brain health and reduces inflammation. Mushroom processing creates large amounts of waste like stems and leftover substrate that actually contain high levels of this beneficial compound. Scientists have developed sustainable methods to extract ergothioneine from this waste, creating opportunities for new health supplements and functional foods while reducing waste and supporting environmental sustainability.

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Association of mushroom consumption with all-cause and cause-specific mortality among American adults: prospective cohort study findings from NHANES III

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This study followed over 15,000 American adults for nearly 20 years and found that people who ate mushrooms had a lower risk of dying from any cause compared to those who didn’t eat mushrooms. The more mushrooms people ate, the greater the benefit. Replacing red or processed meat with mushrooms was associated with even greater longevity benefits. Mushrooms’ beneficial effects likely come from their high antioxidant content, particularly compounds called ergothioneine and glutathione.

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Construction of a genetic linkage map and detection of quantitative trait locus for the ergothioneine content in tamogitake mushroom (Pleurotus cornucopiae var. citrinopileatus)

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Researchers created the first genetic map of tamogitake mushrooms to identify genes controlling ergothioneine content. Ergothioneine is an antioxidant compound that provides health benefits like fighting inflammation and protecting brain health. They found one key genetic marker that reliably predicts which mushrooms will have high ergothioneine levels, enabling farmers to selectively breed mushrooms with enhanced health benefits.

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Centesimal Composition, Bioactive Compounds, Antioxidant and α-Glucosidase Inhibitory Activities of Commercial Edible Oyster Mushrooms at Different Maturity Stages in Northern Thailand

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This study examined how oyster mushrooms change nutritionally and chemically as they mature from young to fully grown. Researchers found that while mature mushrooms have more overall nutrients and starch-like compounds, younger middle-stage mushrooms have higher levels of beneficial antioxidant compounds and special substances that may help manage blood sugar. The findings suggest that when and how you harvest mushrooms matters for what health benefits they provide, helping farmers and food makers decide when to pick mushrooms based on what they want to produce.

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Safe and Effective Antioxidant: The Biological Mechanism and Potential Pathways of Ergothioneine in the Skin

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Ergothioneine is a natural compound found in certain fungi and bacteria that acts like a powerful antioxidant in the body. When applied to skin, it can protect against damage from sun exposure and environmental pollution, reduce signs of aging, and help calm inflammation. It’s particularly special because it automatically travels to damaged areas in the skin where it’s needed most, making it an efficient and targeted treatment ingredient for cosmetics.

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