Research Keyword: enzyme engineering

Computer-directed rational engineering of dioxygenase TcsAB for triclosan biodegradation under cold conditions

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Scientists engineered a special enzyme called TcsAB to work better at cold temperatures, enabling it to break down triclosan, a harmful antibacterial chemical that pollutes our water. By using computer simulations and strategic mutations, they created a modified enzyme that degrades triclosan 2.5 times more efficiently at 15°C. When inserted into bacteria, this engineered enzyme helps clean up triclosan pollution in natural environments without requiring energy-intensive heating.

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Enhancing the Substrate Adaptability of Laccase through Ancestral Sequence Reconstruction for Applications in Mycotoxin Detoxification

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Researchers used evolutionary analysis to redesign a fungal enzyme called laccase to better detoxify harmful mold toxins found in grains. The new engineered enzyme (LacANC278) can break down both aflatoxin and zearalenone toxins much more effectively than the original enzyme, and converts them into less harmful substances. This enzyme works without expensive helper chemicals and works well at room temperature, making it practical for treating contaminated corn and other grains.

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Vinigrol Tricyclic Scaffold Biosynthesis Employs an Atypical Terpene Cyclase and a Multipotent Cyclization Cascade

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Scientists have discovered how a fungus produces vinigrol, a complex molecule with potential health benefits including lowering blood pressure and reducing inflammation. Using advanced computational tools and genetic engineering, researchers identified the specific genes and enzymes the fungus uses to build this molecule’s intricate three-ring structure. By modifying a key enzyme, they were able to create an entirely new diterpene molecule that doesn’t exist in nature, demonstrating the potential to engineer biological systems to produce novel medicinal compounds.

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Bioinformatics-aided identification, characterization and applications of mushroom linalool synthases

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Scientists discovered a special enzyme from mushrooms that efficiently produces linalool, a fragrance ingredient found in most perfumes and cosmetics. This fungal enzyme is much more efficient and selective than similar enzymes from plants or bacteria, making it ideal for mass-producing natural linalool through fermentation. The study used advanced computer analysis to identify the enzyme and revealed specific parts of the enzyme responsible for its excellent performance, which could help design even better enzymes in the future.

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