energy metabolism – mycolab.ai

Inhibitory and synergistic effects of volatile organic compounds from bat caves against Pseudogymnoascus destructans in vitro

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Researchers discovered that two natural compounds found in bat cave environments—isovaleric acid and ethyl methyl carbonate—can effectively kill the fungus that causes white-nose syndrome in bats. When used together, these compounds work even better than alone, disrupting the fungus’s cell membranes, causing it to produce too many reactive molecules (free radicals), and triggering cell death. This discovery offers hope for developing new treatments to protect bat populations that have been devastated by this disease in North America.

Impact of energy metabolism pathways in promoting phytoremediation of cadmium contamination by Bacillus amyloliquefaciens Bam1

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Researchers developed genetically modified bacteria (Bacillus amyloliquefaciens) that produce more energy to better survive in cadmium-contaminated soil. These enhanced bacteria can then help tomato plants absorb and remove cadmium pollution from the soil more effectively. The best-performing modified strain increased cadmium accumulation in tomatoes by nearly 1.9 times compared to the original bacteria, offering a promising biological solution for cleaning contaminated agricultural soils.

Evaluation of Anticancer Potential of Ganoderma lucidum on MCF-7 Breast Cancer Cells Through Genetic Transcription of Energy Metabolism

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Researchers tested extracts from Ganoderma lucidum (Reishi mushroom) against breast cancer cells in the laboratory. They found that the methanol extract was particularly effective at killing cancer cells while leaving healthy cells relatively unharmed. The mushroom works by disrupting the cancer cells’ metabolism and triggering programmed cell death, making it a promising natural treatment option that could complement conventional cancer therapies.

The very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase Phs1 regulates ATP levels and virulence in Cryptococcus neoformans

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Researchers found that a protein called Phs1, which helps Cryptococcus neoformans (a dangerous fungus) produce essential fatty acids, is important for the fungus to cause disease. When this protein was removed, the fungus produced less melanin (a pigment), couldn’t grow well at body temperature, and had a weaker cell wall. Most importantly, the fungus produced less energy (ATP) and was much less deadly in infected mice, suggesting that blocking Phs1 could potentially be a new way to treat cryptococcal infections.

Antifungal efficacy and mechanisms of Bacillus licheniformis BL06 against Ceratocystis fimbriata

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Researchers discovered that a beneficial bacterium called Bacillus licheniformis BL06 can effectively prevent sweet potato black rot, a fungal disease that causes major crop losses worldwide. When applied to sweet potatoes, this bacterium reduces disease damage by interfering with the fungus’s ability to grow, form spores, and survive. The study reveals that the bacterium works by disrupting the fungus’s cell structure and energy production, making it a promising natural alternative to chemical fungicides.

Differential hypo-osmotic stress responses and regulatory mechanisms of Aspergillus sydowii in amphipod guts and hadal sediments

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Scientists discovered a new fungus living in the guts of deep-sea amphipods and studied how it survives in extreme pressure and low-salt environments. By comparing this gut fungus with a similar fungus from deep-sea sediments, they found that the gut fungus is better adapted to low-salt conditions and produces different protective chemicals. The study reveals that fungi evolve different survival strategies depending on where they live, using changes in cell walls and energy production to handle environmental stress.

Carabrone inhibits Gaeumannomyces tritici growth by targeting mitochondrial complex I and destabilizing NAD⁺/NADH homeostasis

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Researchers identified how carabrone, a natural compound from plants, kills a fungus that causes wheat disease. The compound works by blocking a key energy-producing system (complex I) inside the fungus’s cells, which prevents it from producing enough energy to survive. This discovery is important because many current fungicides are losing effectiveness due to resistance, and this compound offers a new way to attack fungi. The findings could help develop new and more effective fungicides for protecting crops.

Inhibition Mechanism of Cinnamomum burmannii Leaf Essential Oil Against Aspergillus flavus and Aflatoxins

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This research shows that essential oil from cinnamon leaves can effectively prevent a dangerous fungus (Aspergillus flavus) from contaminating stored foods like peanuts and grains, and stops it from producing a cancer-causing toxin called aflatoxin. The oil works by damaging the fungus’s cell membrane, disrupting its energy production, and triggering stress responses. Ten main aromatic compounds in the oil, especially eucalyptol and borneol, are responsible for this protective effect. This suggests cinnamon leaf oil could be used as a natural, safe alternative to chemical fungicides for protecting stored food.

Energy Metabolism Enhance Perylenequinone Biosynthesis in Shiraia sp. Slf14 through Promoting Mitochondrial ROS Accumulation

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Scientists studied two similar fungi to understand how one produces more of a beneficial compound called perylenequinones (PQs), which have medical uses against infections and cancer. They discovered that the high-producing strain uses energy more efficiently, which causes tiny structures in the cells called mitochondria to produce reactive molecules (ROS). These reactive molecules trigger the fungus to make more PQs as a protective response. By controlling these processes, researchers can potentially improve the production of this valuable medicine.

Differential hypo-osmotic stress responses and regulatory mechanisms of Aspergillus sydowii in amphipod guts and hadal sediments

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Scientists isolated a fungus from the gut of deep-sea amphipods in the Mariana Trench and discovered how it uniquely adapts to low-salt conditions. Unlike other fungal strains from different habitats, this gut fungus showed special abilities to survive and even thrive when salt levels dropped dramatically. The researchers found that the fungus rapidly rewired its genes and cellular structures to maintain water balance and protect itself, revealing how life in extreme deep-sea environments drives evolution of novel survival strategies.

Research Keyword: energy metabolism