Research Keyword: EMT

Recent Advances in the Use of Ganoderma lucidum and Coriolus versicolor Mushrooms to Enhance the Anticancer Efficacy of EGFR-Targeted Drugs in Lung Cancer

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This review explores how two medicinal mushrooms traditionally used in Asian medicine—Lingzhi and Yunzhi—can enhance the effectiveness of lung cancer drugs (EGFR-TKIs) and help overcome drug resistance. These mushrooms contain special compounds that can fight cancer in multiple ways, boost the immune system, and reduce side effects. The research suggests that combining these mushrooms with standard cancer treatments may improve outcomes for lung cancer patients.

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Methods for Overcoming Chemoresistance in Head and Neck Squamous Cell Carcinoma: Keeping the Focus on Cancer Stem Cells, a Systematic Review

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Head and neck cancer is often resistant to chemotherapy because of cancer stem cells that survive treatment and cause recurrence. This review examined 31 studies on methods to overcome this resistance, finding that natural products like mushrooms (Ganoderma lucidum), plants (sulforaphane from broccoli, curcumin from turmeric), and synthetic compounds can enhance chemotherapy effectiveness when combined with traditional drugs. These approaches work by targeting the specific pathways that allow cancer stem cells to survive, potentially improving treatment outcomes while reducing required drug doses and side effects.

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