Research Keyword: elicitation

Production of fungal hypocrellin photosensitizers: Exploiting bambusicolous fungi and elicitation strategies in mycelium cultures

Hypocrellins are powerful compounds from fungi that can treat cancers and infections through light-activated therapy. Since wild sources are limited, scientists are growing these fungi in laboratory cultures and using special techniques to boost production. This review summarizes the best methods for producing hypocrellins, from choosing the right fungal strains to optimizing growing conditions and using natural stimulants to increase yields.

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Glucose-6-Phosphate Dehydrogenase Modulates Shiraia Hypocrellin A Biosynthesis Through ROS/NO Signaling in Response to Bamboo Polysaccharide Elicitation

Researchers discovered that a specific enzyme called glucose-6-phosphate dehydrogenase (G6PDH) controls the production of hypocrellin A, a powerful therapeutic compound found in Shiraia fungi. When bamboo polysaccharides are added to fungal cultures, they trigger G6PDH activity, which then increases the production of signaling molecules that boost hypocrellin A biosynthesis. This finding could lead to better ways to produce this promising cancer-fighting photosensitizer at industrial scales using simple, cost-effective methods.

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Endophytic Alternaria alternata Culture-Derived Elicitor Promotes Growth and Antibacterial Activity in Kalanchoe laetivirens

Researchers cultivated medicinal Kalanchoe plants in controlled laboratory conditions and exposed them to a powdered form of a beneficial fungus (Alternaria alternata). The plants treated with this fungal extract grew larger, developed more roots, and produced greater amounts of antibacterial compounds compared to untreated plants. The treated plants were especially effective at stopping the growth of two common disease-causing bacteria (E. coli and S. aureus). This approach could lead to more efficient production of plant-based medicines.

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