Research Keyword: efflux pump inhibition

Green-Synthesized Nanomaterials from Edible and Medicinal Mushrooms: A Sustainable Strategy Against Antimicrobial Resistance

Scientists are developing a new weapon against antibiotic-resistant bacteria using mushrooms. These special nanoparticles derived from edible and medicinal mushrooms can kill harmful bacteria in multiple ways without the toxic chemicals used in traditional manufacturing. The nanoparticles work by disrupting bacterial membranes, creating harmful molecules called free radicals, and even boosting your body’s natural immune response. This environmentally friendly approach could become an important tool in fighting dangerous infections that don’t respond to current antibiotics.

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Leveraging synthetic genetic array screening to identify therapeutic targets and inhibitors for combatting azole resistance in Candida glabrata

Candida glabrata is a dangerous fungus causing serious infections that is becoming resistant to antifungal drugs. Researchers used a genetic screening technique to find genes that interact with drug resistance mutations and identified methotrexate (a drug already used for arthritis) as a potential partner for fluconazole treatment. When combined, these drugs work better together against resistant strains of the fungus, offering hope for treating these stubborn infections.

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Progress of Antimicrobial Mechanisms of Stilbenoids

Stilbenoids are natural compounds found in plants that can fight harmful bacteria and fungi in multiple ways. Unlike traditional antibiotics that only kill microbes, stilbenoids can also prevent infections by disrupting biofilm formation and weakening pathogen virulence. These compounds show promise in combating drug-resistant infections without promoting further resistance development, making them valuable candidates for new antibiotic medicines.

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