Research Keyword: efflux pump

Aspergillus fumigatus ctf1 – a novel zinc finger transcription factor involved in azole resistance

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A. fumigatus is a dangerous fungal infection that kills many immunocompromised patients and increasingly resists common antifungal drugs. Researchers identified a key protein called ctf1 that helps the fungus resist the drug voriconazole by pumping it out of fungal cells and altering the fungal cell membrane. Understanding how ctf1 works could lead to new treatments for these difficult-to-treat infections.

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Overexpression of efflux pump and biofilm associated genes in itraconazole resistant Candida albicans isolates causing onychomycosis

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Researchers studied why some fungal nail infections caused by Candida albicans stop responding to the antifungal drug itraconazole. They found that resistant fungal cells have higher activity of genes that pump the drug out of cells and produce slimy protective coatings called biofilms. These resistant fungi also formed less dense biofilms when the drug was present from the start. Understanding these resistance mechanisms could help develop new treatments by targeting the pump systems or breaking down the protective biofilm layers.

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