Research Keyword: effector protein

NtCML19 Is Recruited by Tobacco to Interact With the Deacetylase Protein RsDN3377 of Rhizoctonia solani AG3-TB, Inhibiting Fungal Infection

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Tobacco plants are under attack from a fungal disease caused by Rhizoctonia solani. Scientists discovered that this fungus produces a protein called RsDN3377 that helps it grow and infect plants. However, tobacco plants have evolved a defense protein called NtCML19 that recognizes RsDN3377 and triggers an immune response to fight off the infection. By engineering tobacco plants to produce more NtCML19, researchers showed they could make the plants more resistant to the disease, suggesting a potential new strategy for protecting crops.

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A broad-spectrum anti-fungal effector dictates bacterial-fungal interkingdom interactions

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Scientists discovered that a common soil bacterium called Acidovorax citrulli has a sophisticated weapon to fight dangerous fungi. This bacterium uses a needle-like structure to inject a toxic protein called TseN directly into fungal cells, where it damages the fungal DNA and causes death. This new discovery is particularly exciting because it works against drug-resistant fungi like Candida auris that are increasingly hard to treat. Tests in mice confirmed that this bacterial attack significantly reduces fungal infections on skin.

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Inhibition of RNase to Attenuate Fungal-Manipulated Rhizosphere Microbiome and Diseases

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A fungal pathogen that causes root rot in soybeans and other crops uses a toxic protein called Fg12 to kill beneficial bacteria in the soil that would otherwise protect plants. Scientists discovered that guanosine monophosphate (GMP), a simple chemical compound, can block this toxic protein. When applied to soil, GMP protects plants by allowing beneficial bacteria to survive and fight the fungal infection.

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