The Gcn5 lysine acetyltransferase mediates cell wall remodeling, antifungal drug resistance, and virulence of Candida auris
mycolabadmin
Candida auris is a dangerous fungal infection that resists many standard antifungal drugs. Researchers discovered that a protein called Gcn5 helps this fungus survive both drugs and the body’s immune system. By targeting Gcn5 with a new compound called CPTH2, scientists showed they could make the fungus more vulnerable to standard treatments like caspofungin, suggesting a promising new approach to fighting these infections.