Echinocandin resistance

Severe Saprochaete capitata fungemia presenting as micafungin breakthrough hepatosplenic lesions in an immunocompromised patient: case report

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A 70-year-old woman with blood cancer developed a serious fungal blood infection caused by Saprochaete capitata, a rare soil fungus, despite taking preventive antifungal medication. The infection spread to her liver and spleen, creating multiple lesions and a dangerous aneurysm. Doctors successfully treated her with a combination of three antifungal drugs, particularly voriconazole, which proved more effective than the initial preventive medication. This case highlights how rare fungi can cause severe infections in cancer patients and the importance of recognizing when standard preventive treatments are not working.

Magnusiomyces capitatus bloodstream infection in a patient with acute monocytic leukemia: A rare case report

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A 26-year-old patient with acute leukemia developed a serious fungal blood infection caused by Magnusiomyces capitatus, a rare organism found in environmental sources. The infection was confirmed using advanced molecular techniques and showed resistance to common antifungal drugs but responded to amphotericin B treatment. This case highlights how important it is for doctors to consider unusual fungi in severely immunocompromised patients and to use modern diagnostic methods for accurate identification and tailored treatment.

Aspergillus latus: A cryptic causative agent of aspergillosis emerging in Japan

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Researchers in Japan discovered that a dangerous fungus called Aspergillus latus, previously unknown in the country, has been causing infections since at least 2013. This fungus is difficult to identify because it looks similar to other related species and is actually a hybrid created from two different Aspergillus species. The study found seven cases of this fungus in clinical samples and discovered that it is resistant to some common antifungal medications, making accurate identification crucial for proper patient treatment.

Urosepsis From Nephrolithiasis Caused by Candida glabrata: A Rare Etiology of Urinary Sepsis in an Immunocompetent Patient

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A 41-year-old man with kidney stones developed a serious bloodstream infection caused by Candida glabrata, a type of yeast fungus that rarely infects healthy people. Although he initially received antibiotics, his condition worsened until doctors identified the fungal infection through blood tests. After placing a drainage tube in his kidney and treating him with an antifungal medication called micafungin, he recovered well. This case highlights the importance of considering fungal infections when standard antibiotics fail to treat kidney stone-related infections.

Prevalence and antifungal susceptibility profiles of Candida isolates among patients with candiduria: a multiplex PCR assay

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Researchers studied yeast infections in urine from hospitalized patients using advanced molecular testing. They found that while Candida albicans was most common, other yeast species were becoming more resistant to antifungal medications. The study used a 21-tube PCR test to identify different yeast species and tested which medications worked best against them. Results showed that newer yeast species were much more likely to resist commonly used antifungal drugs like fluconazole.

Geotrichosis Due to Magnusiomyces capitatus: A Severe Emerging Invasive Fungal Disease

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A 71-year-old man with cancer undergoing chemotherapy developed a rare and serious fungal blood infection caused by Magnusiomyces capitatus. Despite treatment with antifungal medications, the infection spread throughout his body and he died 10 days after admission. This case highlights how some fungi can resist common antifungal drugs and the importance of quickly identifying the exact type of fungus causing an infection to choose the right treatment.

Is metabolic generalism the Breakfast of Champions for pathogenic Candida species?

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This review examines how different Candida species, including the common cause of yeast infections (C. albicans) and the more dangerous bloodstream pathogen (C. glabrata), survive in the human body. While most pathogenic Candida species are metabolic generalists that can eat many different nutrients, the review shows that C. glabrata is a specialist that has found alternative strategies to thrive. Understanding these metabolic strategies is important for developing better treatments and fighting antifungal resistance.

Should all hospitalised patients colonised with Candida auris be considered for isolation?

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Candida auris is a dangerous yeast found in hospitals that can spread quickly between patients and is very difficult to treat. Healthcare experts in the Netherlands have decided that all hospital patients carrying this fungus should be isolated in single rooms, even if their strain is susceptible to antifungal drugs, because the infection can develop resistance quickly and cause serious illness. This strict isolation approach helps prevent outbreaks and protects vulnerable patients from developing life-threatening blood infections.

First case of fungemia caused by a rare and pan-echinocandin resistant yeast Sporopachydermia lactativora in China

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A 37-year-old woman with leukemia developed a rare blood infection caused by a yeast called Sporopachydermia lactativora, which had never been documented to cause bloodstream infection in China before. This yeast is naturally resistant to a common class of antifungal drugs called echinocandins, making it particularly challenging to treat. However, the patient responded well to a different antifungal medication called voriconazole and fully recovered. The researchers suggest that this unusual yeast should be monitored in hospitals as it could become a more common infection in vulnerable patients.

Magnusiomyces capitatus bloodstream infection in a patient with acute monocytic leukemia: A rare case report

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A 26-year-old patient with acute leukemia developed a rare fungal bloodstream infection caused by Magnusiomyces capitatus during cancer treatment. The infection was identified through advanced laboratory techniques including DNA sequencing and mass spectrometry. The patient was successfully treated with amphotericin B, highlighting the importance of rapid and accurate fungal identification for better patient outcomes.

Research Keyword: Echinocandin resistance